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. 2015 Sep 23;2015(32):6965–6982. doi: 10.1002/ejoc.201500852

Scheme 16.

Scheme 16

a) Amination/lactamization cascade initiated by an ω-TA-catalyzed step giving access to valuable lactams such as 4-phenylpyrrolidin-2-one, a precursor of GABA derivatives. b) The practical applicability of this cascade was shown in the chemo-enzymatic synthesis of the API niraparib.