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. 2015 Dec 23;12:241. doi: 10.1186/s12974-015-0459-5

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© Jellema et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Study design. Fetuses were instrumented at a gestational age (GA) of 102 days. After a recovery period of 4 days, fetuses were subjected to 25 min of umbilical cord occlusion (UCO) or sham. One hour and 4 days after UCO or sham, fetuses received either intravenous MAPC (10 million cells, closed arrow) or saline 0.9 % (open arrow). After a 7-day reperfusion period, brain tissue was collected. Abbreviations: in instrumentation, HI hypoxia-ischemia, SAL saline, MAPC multipotent adult progenitor cells