Table 1.

Data of DMI, milk production, milk composition and metabolites, cytokines, and APP in the serum of dairy cows with (n = 6) and without subclinical mastitis (SCM) during the periparturient period

	Groupa			Effect,b P-value
Item	SCM	CON	SEM	Hs	Wk	Hs × Wk
DMIc (kg/d)	16.90	18.64	0.72	0.02	<0.01	0.09
Milk productiond (kg/d)	33.76	42.16	2.52	0.04	<0.01	0.37
Milk compositione (g/kg, unless otherwise stated)
Fat	3.67	3.84	0.23	0.63	0.24	0.23
Protein	2.92	2.86	0.05	0.39	0.04	0.19
Fat:protein ratio	1.27	1.37	0.10	0.51	0.24	0.23
Lactose	4.59	4.56	0.05	0.72	0.03	0.86
SCC (103 cells/mL)	628.44	29.38	124.45	<0.01	0.20	0.21
Milk urea N (mg/dL)	17.43	15.61	1.02	0.24	0.53	0.38
TS	12.21	12.21	0.20	0.98	0.40	0.44
Serum parametersf
Lactate (μmol/L)	3,043.38	2,242.94	149.29	<0.01	0.04	0.08
NEFA (mmol/L)	205.46	397.17	64.62	0.07	<0.01	0.14
BHBA (μmol/L)	520.81	596.03	73.09	0.50	<0.01	0.65
IL-1 (pg/mL)	299.19	296.62	4.72	0.71	<0.01	0.04
IL-6 (pg/mL)	19.05	26.70	6.42	0.47	0.15	0.10
TNF (ng/mL)	0.52	0.19	0.04	<0.01	<0.01	<0.01
Haptoglobin (mg/mL)	0.14	0.15	0.01	0.37	<0.01	<0.01
SAA (ug/mL)	23,915	8,514.32	2,517.79	<0.01	0.16	0.40

^aCON = cows without subclinical mastitis (health control); SCM = cows with subclinical mastitis

^bEffect of health status (Hs), sampling week (Wk), and health status by sampling week interaction (Hs × Wk)

^cDry matter intake was calculated from week -8 to +8 relative to parturition

^dMilk production was calculated from week +1 to +8 relative to parturition

^eMilk compositions were determined on week +2, +3, +5, +7 relative to parturition

^fSerum parameters were calculated from week -8, -4, disease, and +4 relative to parturition