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. 2015 Dec 24;12:242. doi: 10.1186/s12974-015-0462-x

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© Li et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — ISG15 and PKR protein expression in the spinal cord of mock- and TMEV-infected C57BL/6 mice. a Few cells express ISG15 proteins in TMEV-infected SJL/J mice at 98 dpi. b Many endothelial cells, astrocytes, and neurons express ISG15 proteins in TMEV-infected C57BL/6 mice at 98 dpi. c Low expression of PKR proteins in TMEV-infected SJL/J mice at 98 dpi. d High expression of PKR proteins in oligodendrocytes, microglia/macrophages, and neurons of TMEV-infected C57BL/6 mice at 98 dpi. Immunohistochemistry visualized by the avidin-biotin-peroxidase complex method with 3,3-diaminobenzidine as substrate and counterstaining with Mayer’s hematoxylin. Bar 100 μm