Table 5.
Estimated country-level impact of RTS,S vaccination
| Country | Number of vaccinees | Median (95 % CI) | |||
|---|---|---|---|---|---|
| Clinical malaria cases averted | Severe malaria cases averted | Malaria hospitalizations averted | Malaria deaths averted | ||
| Vaccination at 6, 10 and 14 weeks | |||||
| Burkina Faso | 673,961 | 234,951 (2090, 477,517) | 4182 (−6846, 14,515) | 3474 (−5688, 12,059) | 1092 (−1788, 3,790) |
| Democratic Republic of Congo | 2,177,255 | 590,733 (77,960, 1,114,625) | 13, 943 (−22,087, 41,080) | 11, 583 (−18,349, 34,128) | 3641 (−5767, 10,727) |
| Ghana | 739,857 | 180,785 (17,756, 344,188) | 4080 (−8121, 11,908) | 3389 (−6747, 9893) | 1065 (−2121, 3109) |
| Kenya | 1,423,439 | 96,415 (12,032, 189,548) | 2805 (−6042, 9841) | 2330 (−5020, 8176) | 732 (−1578, 2570) |
| Nigeria | 3,641,124 | 1,137,914 (106,434, 2,194,118) | 25,223 (−41,239, 77,330) | 20,955 (−34,261, 64,243) | 6586 (−10,768, 20,192) |
| Tanzania | 1,879,173 | 255,645 (37,085, 478,220) | 6484 (−13,984, 19,374) | 5387 (−11,618, 16,096) | 1693 (−3,652, 5059) |
| Senegal | 469,921 | 36,048 (7275, 67,343) | 1477 (−3337, 4803) | 1227 (−2772, 3990) | 386 (−871, 1254) |
| Uganda | 1,462,572 | 411,047 (11,695, 819,896) | 7480 (−14,269, 24,160) | 6214 (−11,854, 20,071) | 1953 (−3726, 6309) |
| 42 countries in sub-Saharan Africa | 25,210,481 | 5,004,489 (474,867, 9,684,160) | 118,736 (−214,795, 372,995) | 98,642 (−178,445, 309,873) | 31,004 (−56,087, 97,396) |
| Vaccination at 6, 7.5 and 9 months | |||||
| Burkina Faso | 488,861 | 562,795 (327,910, 669,793) | 9985 (−54, 19,791) | 8295 (−45, 16,441) | 2607 (−14, 5168) |
| Democratic Republic of Congo | 1,551,474 | 1,414,342 (923,277, 1,657,736) | 28,922 (1270, 54,286) | 24,028 (1,055, 45,099) | 7552 (332, 14,175) |
| Ghana | 541,400 | 468,774 (323,528, 549,868) | 8254 (82, 15,470) | 6857 (69, 12,852) | 2155 (22, 4040) |
| Kenya | 1,041,584 | 260,446 (189,489, 307,495) | 5,641 (−636, 11,453) | 4,686 (−528, 9,515) | 1473 (−166, 2991) |
| Nigeria | 2,624,558 | 2,749,346 (1,748,642, 3,234,411) | 54,546 (1758, 103,606) | 45,315 (1460, 86,073) | 14,243 (459, 27,054) |
| Tanzania | 1,382,820 | 693,506 (515,124, 811,055) | 12,453 (−451, 23,670) | 10,346 (−375, 19,665) | 3252 (−118, 6181) |
| Senegal | 344,479 | 101,544 (80,459, 118,862) | 2741 (−315, 5441) | 2277 (−262, 4520) | 716 (−82, 1421) |
| Uganda | 1,072,051 | 1,038,791 (657,896, 1,229,031) | 16,671 (−72, 32,293) | 13,850 (−60, 26,828) | 4353 (−19, 8432) |
| 42 countries in sub-Saharan Africa | 18,313,808 | 12,484,309 (8,242,412, 14,696,728) | 250,448 (−433, 481,819) | 208,064 (−359, 400,280) | 65,397 (−113, 125,813) |
Estimated numbers of vaccinees and median and 95 % CIs for the number of clinical malaria cases, severe malaria cases, malaria hospitalizations and malaria deaths averted by RTS,S vaccination with doses administered either at 6, 10 and 14 weeks or at 6, 7-and-a-half and 9 months
Outcomes are estimated for the annual birth cohort in each country, beginning in 2017 and following the cohort until the age of 10 years, assuming no change in malaria transmission