Fig. 6.
Alleviation by derepression. a Genetic interaction between Gln3 and Gzf3. Representation as described for Fig. 5a. Top GO-BP terms are: gene set 1: generation of precursor metabolites and energy (P = 5.86 × 10−3); gene set 3: de novo pyrimidine nucleobase biosynthetic process (P = 9.58 × 10−5); gene set 4: methionine biosynthetic process (P = 4.78 × 10−3); gene set 5: oxidation reduction process (P = 4.32 × 10−4); gene set 6: generation of precursor metabolites and energy (P = 1.09 × 10−6); gene set 7: oxidation reduction process (P = 0.01); gene set 8: response to pheromone involved in conjugation with cellular fusion (P = 3.12 × 10−4); gene set 9: arginine biosynthetic process (P = 4.44 × 10−3); gene set 10: arginine biosynthetic process (P = 5.45 × 10−3); gene set 11: nucleotide biosynthetic process (P = 1.11 × 10−6); gene set 12: oxidation reduction process (P = 5.28 × 10−6). b Gln3-activated genes (zoom-up of gene set 4 in a). Red label to highlight the known target gene GLN1 [48]. c Gzf3-repressed genes (zoom-up of gene set 2 in a). d Cartoon depicting the proposed relationship between Gln3 and Gzf3. Consequences of individual deletions are indicated in red. e Summarized model to describe the proposed genetic interaction between Gln3 and Gzf3. f Generalized model for “alleviation by derepression”