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. 2015 Dec 24;3:22. doi: 10.1186/s40349-015-0044-5

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© Magnin et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Overview of the BBB permeabilization experiment. The different steps are summed up in the first row. The rodents are shaved and installed in the bed under anesthesia, and a catheter is set in the caudal vein. It is then inserted in the magnet where reference scans (second row, a and b) and positioning procedure are performed using ARFI images and the motors. The BBB permeabilization procedure is performed followed by MR contrast agent injection and post-permeabilization MR image acquisition (c). MB = microbubbles. The red arrow indicates the BBB permeabilization visible by a contrast enhancement on the T₁-weighted image (c)