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. 2015 Dec 24;7:133. doi: 10.1186/s13148-015-0164-3

Table 3.

DNA methylation and time to disease (TTD)

		ZBTB12					LINE-1
TTD class^a	Range^b	Effect size	95 % CI	se	P _TREND	Cochran’s Q	Effect size	95 % CI	se	P _TREND	Cochran’s Q
EPICOR men
TTD class 1	8.89–14.66
TTD class 2	5.23–8.88	−0.0054	−0.0090;−0.0018	0.0018	0.0036		−0.0009	−0.0016;−0.0003	0.0003	0.0044
TTD class 3	0.26–5.20
EPIC-NL men
TTD class 1	6.97–12.31
TTD class 2	3.53–6.86	−0.0093	−0.0182;−0.0005	0.0045	0.0389		−0.0035	−0.0070;0.00003	0.0018	0.0537
TTD class 3	0.23–3.52
Meta-analysis		−0.0059	−0.0093;−0.0027	0.0017	0.0005	0.65^c	−0.0010	−0.0017;−0.0004	0.0003	0.0016	2.03^c
EPICOR women
TTD class 1	8.16–14.02
TTD class 2	4.40–8.06	−0.0056	−0.0106;−0.0007	0.0025	0.0250		−0.0008	−0.0017;0.00004	0.0004	0.0636
TTD class 3	0.33–4.30
EPIC-NL women
TTD class 1	7.35–12.30
TTD class 2	4.40–7.21	−0.0047	−0.0106;0.0011	0.0030	0.1147		−0.0011	−0.0032;0.0010	0.0011	0.2970
TTD class 3	0.04–4.38
Meta-analysis		−0.0053	−0.0091;−0.0015	0.0019	0.0065	0.05^c	−0.0008	−0.0016;−0.0001	0.0004	0.0263	0.07^c

^aHealthy controls (TTD class 0) were used as the reference group. Cases were divided in tertiles (TTD classes 1 to 3)

^bMinimum and maximum TTD (i.e., time lapse in years from enrollment to occurrence of MI) for each class

^cd.f. = 1, P = not significant