Table 1.
Tumour characteristics of the breast cancer specimens
| Cohorts | TCGA | TCGA-sub | RT-qPCR | Ivshina | Schmidt | Symmans | Wang |
|---|---|---|---|---|---|---|---|
| N | 520 | 59 | 71 | 249 | 200 | 298 | 286 |
| Histological type | |||||||
| Ductal | 442 (85.0) | 51 (86.4) | 56 (78.9) | – | – | – | – |
| Lobular | 41 (7.9) | 3 (5.1) | 5 (7.0) | – | – | – | – |
| Mixed and others | 36 (6.9) | 5 (8.5) | 9 (12.7) | – | – | – | – |
| Tumour diameter | |||||||
| ≤2.0 cm | 133 (25.6) | 20 (33.9) | 39 (54.9) | 126 (50.6) | 112 (56.0) | – | – |
| >2.0 cm | 364 (70.0) | 38 (64.4) | 32 (45.1) | 123 (49.4) | 88 (44.0) | – | – |
| Regional lymph nodes | |||||||
| Negative | 253 (48.7) | 25 (42.4) | 34 (47.9) | 159 (63.9) | 200 (100) | 175 (58.7) | 286 (100) |
| Positive | 256 (49.2) | 34 (57.6) | 36 (50.7) | 81 (32.5) | 0 (0) | 112 (37.6) | 0 (0) |
| Distant metastasis | |||||||
| Negative | 491 (94.4) | 57 (96.6) | – | – | – | – | – |
| Positive | 15 (2.9) | 1 (1.7) | – | – | – | – | – |
| TNM stage | |||||||
| I | 89 (17.1) | 13 (22.0) | – | – | – | – | – |
| II | 290 (55.8) | 34 (57.6) | – | – | – | – | – |
| III | 110 (21.2) | 11 (18.6) | – | – | – | – | – |
| IV | 14 (2.7) | 1 (1.7) | – | – | – | – | – |
| Tumour grade | |||||||
| Grade 1 | – | – | 7 (9.9) | 68 (27.3) | 29 (14.5) | – | – |
| Grade 2 | – | – | 25 (35.2) | 126 (50.6) | 136 (68.0) | – | – |
| Grade 3 | – | – | 36 (50.7) | 55 (22.1) | 35 (17.5) | – | – |
| ER status | |||||||
| Negative | 117 (22.5) | 9 (15.3) | 18 (25.4) | 34 (13.7) | – | 0 (0) | 77 (26.9) |
| Positive | 396 (76.2) | 48 (81.4) | 52 (73.2) | 211 (84.7) | – | 298 (100) | 209 (73.1) |
| PR status | |||||||
| Negative | 176 (33.8) | 16 (27.1) | 22 (31.0) | – | – | – | – |
| Positive | 336 (64.6) | 41 (69.5) | 48 (67.6) | – | – | – | – |
| HER2 status | |||||||
| Negative | 361 (69.4) | 48 (81.4) | 60 (84.5) | – | – | – | – |
| Positive | 101 (19.4) | 10 (16.9) | 10 (14.1) | – | – | – | – |
| Triple-negative | |||||||
| True | 72 (13.8) | 7 (11.9) | 11 (15.5) | – | – | – | – |
| False | 448 (86.2) | 52 (89.1) | 60 (84.5) | – | – | – | – |
| PAM50 subtype | |||||||
| Basal-like | 96 (18.5) | 11 (18.6) | – | – | – | – | – |
| HER2-enriched | 58 (11.2) | 4 (6.8) | – | – | – | – | – |
| Luminal A | 231 (44.4) | 32 (54.2) | – | – | – | – | – |
| Luminal B | 127 (24.4) | 12 (20.3) | – | – | – | – | – |
| Normal-like | 8 (1.5) | 0 (0) | – | – | – | – | – |
Data are presented as the number of patients in each subgroup with percentage in the parentheses. Numbers may not sum to total (N) due to missing datadata