Table 2.

Association of Log_e High-Sensitivity C-Reactive Protein With Incident Coronary Heart Disease, Multi-Ethnic Study of Atherosclerosis, 2000–2012

Study Group	CHD Events		Model 1a			Model 2b			Model 3c			Model 4d
	No.	%	HR	95% CI	P for Interactione	HR	95% CI	P for Interactione	HR	95% CI	P for Interactione	HR	95% CI	P for Interactione
Overall	299	6.2	1.13	1.00, 1.28		1.04	0.91, 1.19		1.05	0.92, 1.20		1.06	0.93, 1.21
LDL-C <130 mg/dL	168	5.4	0.94	0.79, 1.10	0.002	0.88	0.74, 1.05	0.007	0.88	0.74, 1.05	0.003	0.89	0.75, 1.06	0.003
LDL-C ≥130 mg/dL	131	7.6	1.43	1.17, 1.75		1.25	1.02, 1.55		1.29	1.05, 1.60		1.29	1.05, 1.60

Abbreviations: CHD, coronary heart disease; CI, confidence interval; HR, hazard ratio; LDL-C, low-density lipoprotein cholesterol.

^a Adjusted for age, sex, race, site, total family income, and educational level.

^b Adjusted for the variables in model 1 and body mass index, diabetes, smoking status, family history of coronary heart disease, systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol level, aspirin use, and antihypertensive therapy.

^c Adjusted for the variables in models 1 and 2 and estimated glomerular filtration rate, macroalbuminuria, microalbuminuria, and coronary artery calcium score.

^d Adjusted for the variables in models 1–3 and interim use of lipid-lowering medication.

^e P value for interaction was examined for the difference in the associations with high-sensitivity C-reactive protein between the LDL-C <130 mg/dL subcohort and the LDL-C ≥130 mg/dL subcohort.