Table 1.
Genes That Determine Resistance to β-Lactam Antibiotics Targeted in PRIMERS I and II
| Antibiotic | bla Gene |
|---|---|
| Ampicillin | CTX-M-1a, CTX-M-2a, CTX-M-8 & -25a, CTX-M-9a, TEM-WT (TEM-1), TEME104K, TEMR164S, TEMR164C, TEMR164H, TEMG238S, TEME240K, TEMA237, SHV-WT (SHV-1), SHVG238S, SHVG238A, SHVE240K, CMY-1/MOX, CMY-2/FOX, KPC, NDM, VIM, IMP, OXA-48 |
| Ampicillin/Sulbactam | SHV-WT (SHV-1), KPC, NDM, VIM, IMP, OXA-48, CMY-1/MOX, CMY-2/FOX |
| Amoxicillin/Clavulanic | KPC, NDM, VIM, IMP, OXA-48, CMY-1/MOX, CMY-2/FOX |
| Piperacillin/Tazobactam | KPC, NDM, VIM, IMP, OXA-48, CMY-1/MOX, CMY-2/FOX |
| Cefazolin (I) | CTX-M-1, CTX-M-2, CTX-M-8 & -25, CTX-M-9, TEMR164S, TEMR164C, TEMR164H, TEMG238S, TEME240K, TEMA237, SHVG238S, SHVG238A, SHVE240K, CMY-1/MOX, CMY-2/FOX, KPC, NDM, VIM, IMP, OXA-48 |
| Cefoxitin (II) | KPC, NDM, VIM, IMP, OXA-48, CMY-1/MOX, CMY-2/FOX |
| Cefotaxime (III) | CTX-M-1, CTX-M-2, CTX-M-8 & -25, CTX-M-9, TEMR164S, TEMR164C, TEMR164H, TEMG238S, TEME240K, TEMA237, SHVG238S, SHVG238A, SHVE240K, CMY-1/MOX, CMY-2/FOX, KPC, NDM, VIM, IMP |
| Ceftriaxone (III) | CTX-M-1, CTX-M-2, CTX-M-8 & -25, CTX-M-9, TEMR164S, TEMR164C, TEMR164H, TEMG238S, TEME240K, TEMA237, SHVG238S, SHVG238A, SHVE240K, CMY-1/MOX, CMY-2/FOX, KPC, NDM, VIM, IMP |
| Ceftazidime (III) | CTX-M-1, CTX-M-2, CTX-M-8 & -25, CTX-M-9, TEMR164S, TEMR164C, TEMR164H, TEMG238S, TEME240K, TEMA237, SHVG238S, SHVG238A, SHVE240K, CMY-1/MOX, CMY-2/FOX, KPC, NDM, VIM, IMP |
| Cefepime (IV) | CTX-M-1, CTX-M-2, CTX-M-8 & -25, CTX-M-9, TEMR164S, TEMR164C, TEMR164H, TEMG238S, TEME240K, TEMA237, SHVG238S, SHVG238A, SHVE240K, CMY-1/MOX, CMY-2/FOX, KPC, NDM, VIM, IMP |
| Aztreonam | CTX-M-1, CTX-M-2, CTX-M-8 & -25, CTX-M-9, TEMR164S, TEMR164C, TEMR164H, TEMG238S, TEME240K, TEMA237, SHVG238S, SHVG238A, SHVE240K, CMY-1/MOX, CMY-2/FOX, KPC |
| Ertapenem | KPC, NDM, VIM, IMP, OXA-48 |
| Imipenem | KPC, NDM, VIM, IMP, OXA-48 |
| Meropenem | KPC, NDM, VIM, IMP, OXA-48 |
a Indicates CTX-M group.