Table 2.

Ethnicity-specific and multi-ethnic meta-analysis of significant (P < 1.9 × 10⁻⁶) and suggestive (P < 1 × 10⁻⁵) signals of association with habitual sleep duration

Population	SNP	Gene	Derived allele	DAF	Beta (SE), min	P	Direction	Phet	N
European Americans	rs17601612	DRD2	C	0.37–0.39	−3.66 (0.72)	7.52 × 10−7	−−−−−−	0.085	18 022
	rs11214607	DRD2	G	0.15–0.16	4.08 (1.02)	4.37 × 10−5	++++++	0.9	18 024
Asian Americans	rs17601612	DRD2	C	0.028	−16.14 (13.56)	0.233	−	N/A	546
	rs11214607	DRD2	G	0.38	2.04 (4.32)	0.64	+	N/A	546
Hispanic Americans	rs17601612	DRD2	C	0.28	−8.46 (3.90)	0.031	−	N/A	1051
	rs11214607	DRD2	G	0.30	5.46 (3.96)	0.169	+	N/A	1050
African Americans	rs17601612	DRD2	C	0.12–0.15	2.46 (2.34)	0.30	−++++	0.7	5546
	rs11214607	DRD2	G	0.07–0.09	3.60 (3.00)	0.23	+−+++	0.9	5546
Discovery meta-analysis	rs17601612	DRD2	C	0.028–0.39	−3.32 (0.70)	1.83 × 10−6	−−−−−−−−−++++	0.054	25 165
	rs11214607	DRD2	G	0.072–0.38	4.08 (0.90)	8.26 × 10−6	+++++++++−+++	1.00	25 166
Replicationa	rs17601612	DRD2	C	0.37–0.39	−2.05 (1.41)	0.15	+−−−	0.55	5 529
	rs11214607	DRD2	G	0.16	3.64 (1.94)	0.061	+++−	0.44	5 529
Combined meta-analysis	rs17601612	DRD2	C	0.028–0.39	−3.07 (0.63)	9.75 × 10−7	−−	0.54	30 694
	rs11214607	DRD2	G	0.072–0.38	4.04 (0.90)	7.76 × 10−6	++	0.60	20 695

DAF, derived allele frequency range in component studies.

^aProxy rs2471854 with pairwise r² = 0.90 in EUR used for replication studies.