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. 2015 Oct 28;25(1):69–82. doi: 10.1093/hmg/ddv449

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© The Author 2015. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Examples of novel constitutive eCGIs in promoter regions. (A) Novel eCGIs are identified in the promoter region of the retinoblastoma binding protein 5 gene RBBP5 (white blocks) which are not currently annotated in UCSC. Experimental eCGIs are identified using methylation data from individual CpG sites in each tissue (colored dots). (B) Novel eCGI at the promoter of the TRIM16 gene (tripartite motif containing 16) on chromosome 17 overlaps with repetitive elements by repeatmasker (red blocks). These genes are ubiquitously expressed, show active promoter chromatin marks and overlap with TSS in CAGE data in B-cell. Additional examples are shown in Supplementary Material, Figure S4.