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. 2015 Dec 24;2(4):ofv155. doi: 10.1093/ofid/ofv155

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© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 6. — The effects of human cytomegalovirus (HCMV) and endothelin receptor type B (ET_BR) blocker, BQ788, on endothelial cells proliferation, migration, vasculogenecity, and leukocyte recruitment. (A) Cell proliferation assay by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) was performed in human umbilical vein cells (HUVECs) uninfected or HCMV-infected, untreated or treated with BQ788 at the indicated time points after infection. Optical density was read at 590 nm with reference wavelength at 670 nm. (B) Light microscopic images (×4) of the wound healing assay were taken at different times after the “scratch” of HUVEC monolayers uninfected or HCMV-infected treated with BQ788. (C) Light microscopic images (×4) of tube formation by HUVEC uninfected or HCMV-infected and treated with BQ788. (D) Light microscopic images of flow adhesion assay in cells stimulated with tumor necrosis factor-α (TNFα) and uninfected or HCMV-infected (left panel). The number of adherent cells was quantified for all the conditions (right panel). Values are mean ± standard deviation; P < .05 was considered to be statistically significant; *P = .01–.05; **P = .001–.01; ***P < .001).