Table 2. Factors associated with development of HCC.
| Characteristics | Univariate HR (95% CI) | P value | Multivariate HR (95% CI) | P value |
|---|---|---|---|---|
| Age (per year) | 1.07 (1.03–1.10) | <0.001 | 1.07 (1.03–1.12) | <0.001 |
| Male (vs. female) | 1.76 (0.88–3.53) | 0.10 | 2.27 (1.11–4.63) | 0.024 |
| ALT (U/L) | 0.99 (0.99–1.00) | 0.40 | ||
| HBV DNA (log10 IU/ml) | 1.39 (1.11–1.76) | 0.004 | 1.74 (1.33–2.29) | <0.001 |
| qHBsAg (log10 IU/ml) | 0.72 (0.43–1.21) | 0.22 | 0.77 (0.42–1.43) | 0.42 |
| Cirrhosis (yes vs. no) | 7.06 (3.12–15.9) | <0.001 | 7.03 (3.02–16.3) | <0.001 |
| AVT duration (/year) | 0.84 (0.71–1.00) | 0.055 | 0.56 (0.45–0.69) | <0.001 |
Abbreviations: HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; ALT, alanine aminotransferase; HBV, hepatitis B virus; qHBsAg, quantitative hepatitis B surface antigen; AVT, antiviral therapy.