Table 5. Cumulative incidence of disease progression and inactive carrier state according to HBV DNA and qHBsAg levels in non-cirrhotic patients, further stratified by age-group.
| Groups | Disease progression | Inactive carrier | ||||
|---|---|---|---|---|---|---|
| Person-years of follow-up | 3 year | 5 year | Person-years of follow-up | 3 year | 5 year | |
| Age < 50 years (n = 180) | ||||||
| Group A (n = 38) | 155 | 0% | 0% | 119 | 25.1% | 39.5% |
| Group B (n = 45) | 172 | 0% | 0% | 163 | 10.1% | 10.1% |
| Group C (n = 35) | 133 | 4.2% | 4.2% | 131 | 3.8% | 7.9% |
| Group D (n = 62) | 238 | 1.8% | 1.8% | 241 | 0% | 0% |
| Age ≥ 50 years (n = 129) | ||||||
| Group A (n = 36) | 121 | 3.6% | 3.6% | 108 | 13.1% | 42.2% |
| Group B (n = 30) | 107 | 3.6% | 3.6% | 93 | 17.5% | 17.5% |
| Group C (n = 32) | 113 | 5.6% | 5.6% | 113 | 0% | 0% |
| Group D (n = 31) | 104 | 3.4% | 3.4% | 108 | 0% | 0% |
Abbreviation: HBV, hepatitis B Virus; qHBsAg, quantitative hepatitis B surface antigen. Group A, B, C and D are those with low HBV DNA plus low qHBsAg levels, low HBV DNA plus high qHBsAg levels, high HBV DNA plus low qHBsAg levels, and high HBV DNA plus high HBV DNA levels, respectively. Cut-off level was 20,000 IU/ml for HBV DNA and 2,500 IU/ml for qHBsAg.