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. 2015 Dec 18;10:13–21. doi: 10.2147/DDDT.S93183

Table S1.

Pharmacokinetic parameters for rhGH and Jintrolong® in healthy adults

Jintrolong® (mg/kg/w)
rhGH (mg/kg/d)
0.1 0.2 0.4 0.067
N 10 10 10 10
Sex Male Male Male Male
Cmax (ng/mL) 105.24±45.37 379.09±109.61 920.69±293.21 30.17±3.20
AUC0–t (ng·h/mL) 4,543.91±2,332.79 25,085.27±9,388.52 74,062.03±28,915.02 232.78±36.60
Tmax (hours) 22.20±9.82 29.40±10.75 40.80±8.39 3.2±1.1
t1/2 (hours) 31.70±4.70 32.19±4.58 30.39±5.93 1.95±0.44
MRT (hours) 40.86±9.18 49.90±7.53 60.92±7.29 6.20±0.39
Vd/F (mL/kg) 1,227.61±592.64 439.44±237.36 268.85±116.80 787.59±155.71
CL/F (mL/kg/h) 26.97±13.86 9.21±4.05 6.31±2.93 284.26±43.47

Note: The results are expressed as the mean ± SD.

Abbreviations: rhGH, recombinant human growth hormone; AUC, area under the concentration vs time curve; MRT, mean residence time; CL, clearance; h, hours; N, number; Cmax, maximal serum concentration; Tmax, time of maximum concentration; t1/2, half-life; Vd/F, apparent volume of distribution; CL/F, apparent total clearance.