Table S1.
Pharmacokinetic parameters for rhGH and Jintrolong® in healthy adults
| Jintrolong® (mg/kg/w)
|
rhGH (mg/kg/d)
|
|||
|---|---|---|---|---|
| 0.1 | 0.2 | 0.4 | 0.067 | |
| N | 10 | 10 | 10 | 10 |
| Sex | Male | Male | Male | Male |
| Cmax (ng/mL) | 105.24±45.37 | 379.09±109.61 | 920.69±293.21 | 30.17±3.20 |
| AUC0–t (ng·h/mL) | 4,543.91±2,332.79 | 25,085.27±9,388.52 | 74,062.03±28,915.02 | 232.78±36.60 |
| Tmax (hours) | 22.20±9.82 | 29.40±10.75 | 40.80±8.39 | 3.2±1.1 |
| t1/2 (hours) | 31.70±4.70 | 32.19±4.58 | 30.39±5.93 | 1.95±0.44 |
| MRT (hours) | 40.86±9.18 | 49.90±7.53 | 60.92±7.29 | 6.20±0.39 |
| Vd/F (mL/kg) | 1,227.61±592.64 | 439.44±237.36 | 268.85±116.80 | 787.59±155.71 |
| CL/F (mL/kg/h) | 26.97±13.86 | 9.21±4.05 | 6.31±2.93 | 284.26±43.47 |
Note: The results are expressed as the mean ± SD.
Abbreviations: rhGH, recombinant human growth hormone; AUC, area under the concentration vs time curve; MRT, mean residence time; CL, clearance; h, hours; N, number; Cmax, maximal serum concentration; Tmax, time of maximum concentration; t1/2, half-life; Vd/F, apparent volume of distribution; CL/F, apparent total clearance.