Table 1.
Pharmacokinetic parameters for rhGH and Jintrolong®
| rhGH at 0.0286 mg/kg/d
|
Jintrolong® at 0.2 mg/kg/w
|
|||||
|---|---|---|---|---|---|---|
| First dose | Seventh dose | P-value | First dose | Sixth dose | P-value | |
| N | 12 | 12 | 12 | 12 | ||
| Cmax (ng/mL) | 20.4±4.1 | 22.4±3.8 | 0.2283 | 327±70 | 340±44 | 0.5915 |
| AUC0–168 h (ng·h/mL) | 103±21 | 104±19 | 0.9428 | 34,837±8,235 | 37,229±7,911 | 0.5954 |
| Tmax (hours) | 3.8±0.5 | 3.8±0.8 | 0.7648 | 43.0±14.9 | 38.0±14.3 | 0.3594 |
| t1/2 (hours) | 2.3±0.4 | 2.3±0.8 | 0.9400 | 33.0±5.7 | 34.0±8.1 | 0.7933 |
Note: The results are expressed as the mean ± SD.
Abbreviations: rhGH, recombinant human growth hormone; AUC, area under the concentration vs time curve; N, number; Cmax, maximal serum concentration; Tmax, time of maximum concentration; t1/2, half-life.