Table 2.
The accumulated change in AUC (AUCchange) from baseline for serum IGF-1 during the course of seven doses of Jintropin AQ® and the first and sixth doses of Jintrolong® in children with GHD (n=12)
| Group | Treatment | AUCtotal | AUCbaseline | AUCchange |
|---|---|---|---|---|
| rhGH | 0.0286 mg/kg/d ×7 | 23,133.2±8,316.5 | 6,298.6±2,861.8 | 16,834.6±6,732.1 |
| Jintrolong® first | 0.2 mg/kg/w | 28,097.5±6,858.0 | 6,123.6±2,797.8 | 21,973.9±5,886.9 |
| Jintrolong® sixth | 0.2 mg/kg/w | 37,541.7±9,928.2 | 18,900.0±9,015.6 | 18,641.7±4,783.0 |
Note: The results are expressed as the mean ± SD.
Abbreviations: AUC, area under the concentration vs time curve; IGF-1, insulin-like growth factor-1; GHD, growth hormone deficiency; rhGH, recombinant human growth hormone.