Table 2.
Subgroup analysis of patients without UGIB.
| Variables | Total Pts (n=118) | Moderate-large varices Pts (n=62) | No-Mild varices Pts (n=56) | P value | With varices Pts (n=68) | Without varices Pts (n=50) | P value |
|---|---|---|---|---|---|---|---|
| Sex (male/female) | 69/49 | 36/26 | 33/23 | 0.924 | 38/30 | 31/19 | 0.505 |
| Age (years) | 55.09±11.02 | 55.89±10.86 | 54.21±11.24 | 0.41 | 54.90±11.59 | 55.35±10.32 | 0.828 |
| Etiology of liver diseases, n (%) | 0.041 | 0.161 | |||||
| Hepatitis B virus | 28 (23.7) | 19 (30.6) | 9 (16.1) | 19 (27.9) | 9 (18.0) | ||
| Hepatitis C virus | 8 (6.8) | 5 (8.1) | 3 (5.4) | 6 (8.8) | 2 (4.0) | ||
| Hepatitis B virus + Hepatitis C virus | 1 (0.8) | 1 (1.6) | 0 (0) | 1 (1.5) | 0 (0) | ||
| Alcohol | 30 (25.4) | 13 (21.0) | 17 (30.4) | 14 (20.6) | 16 (32.0) | ||
| Hepatitis B virus + Alcohol | 8 (6.8) | 5 (8.1) | 3 (5.4) | 5 (7.4) | 3 (6.0) | ||
| Unknown | 33 (28.0) | 11 (17.7) | 22 (39.3) | 15 (22.1) | 18 (36.0) | ||
| Others | 10 (8.4) | 8 (12.9) | 2 (3.6) | 8 (11.8) | 2 (4) | ||
| Ascites, n (%) | 0.524 | 0.172 | |||||
| No | 69 (58.5) | 34 (54.8) | 35 (62.5) | 35 (51.5) | 34 (68.0) | ||
| Mild | 18 (15.3) | 9 (14.5) | 9 (16.1) | 13 (19.1) | 5 (10.0) | ||
| Moderate to severe | 31 (26.3) | 19 (30.6) | 12 (21.4) | 20 (29.4) | 11 (22.0) | ||
| Hepatic encephalopathy, n (%) | 0.34 | 0.389 | |||||
| No | 117 (99.2) | 61 (98.4) | 56 (100) | 67 (98.5) | 50 (100) | ||
| Grade I–II | 1 (0.8) | 1 (1.6) | 0 (0) | 1 (1.5) | 0 (0) | ||
| Grade III–IV | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Varices, n (%) | NA | NA | |||||
| No | 50 (42.4) | 0 (0) | 50 (89.3) | 0 (0) | 50 (100) | ||
| Mild | 6 (5.1) | 0 (0) | 6 (10.7) | 6 (8.8) | 0 (0) | ||
| Moderate | 20 (16.9) | 20(32.3) | 0 (0) | 20 (29.4) | 0 (0) | ||
| Severe | 42 (35.6) | 42 (67.7) | 0 (0) | 42 (61.8) | 0 (0) | ||
| Laboratory tests | |||||||
| RBC | 3.72±0.74 | 3.68±0.69 | 3.76±0.79 | 0.571 | 3.68±0.68 | 3.78±0.82 | 0.459 |
| Hb | 116.69±25.85 | 115.45±25.58 | 118.07±26.30 | 0.585 | 115.12±25.03 | 118.84±27.03 | 0.442 |
| WBC | 4.26±2.29 | 3.94±2.39 | 4.62±2.13 | 0.106 | 3.91±2.34 | 4.74±2.14 | 0.051 |
| PLT | 90.72±59.50 | 76.92±50.82 | 106.00±64.91 | 0.007 | 76.76±50.41 | 109.70±65.88 | 0.003 |
| TBIL | 31.02±36.80 | 30.39±21.34 | 31.72±48.73 | 0.845 | 30.15±20.97 | 32.20±51.28 | 0.767 |
| DBIL | 16.79±29.45 | 15.40±17.11 | 18.33±38.93 | 0.592 | 15.33±16.68 | 18.77±41.03 | 0.533 |
| IBIL | 14.19±9.92 | 14.94±8.40 | 13.37±11.39 | 0.394 | 14.75±8.35 | 13.44±11.78 | 0.482 |
| ALB | 35.30±6.13 | 34.04±5.84 | 36.70±6.20 | 0.018 | 33.97±5.98 | 37.11±5.92 | 0.006 |
| ALT | 55.03±122.69 | 45.95±46.68 | 65.07±171.49 | 0.4 | 44.84±44.79 | 68.88±181.27 | 0.295 |
| AST | 70.42±102.52 | 74.45±106.22 | 65.95±99.02 | 0.655 | 72.15±101.98 | 68.06±104.24 | 0.832 |
| ALP | 120.34±87.20 | 124.76±99.60 | 115.46±71.59 | 0.565 | 126.68±100.69 | 111.73±64.50 | 0.36 |
| GGT | 143.04±223.66 | 138.85±240.15 | 147.68±205.94 | 0.832 | 142.13±238.07 | 144.28±204.81 | 0.959 |
| BUN | 5.61±3.35 | 5.37±2.18 | 5.89±4.29 | 0.402 | 5.37±2.11 | 5.94±4.52 | 0.365 |
| Cr | 64.85±55.02 | 58.35±27.04 | 72.05±74.35 | 0.178 | 57.34±26.15 | 75.06±78.15 | 0.084 |
| PT | 15.07±2.41 | 15.42±2.20 | 14.67±2.58 | 0.093 | 15.45±2.38 | 14.55±2.41 | 0.044 |
| APTT | 42.74±6.58 | 43.31±6.43 | 42.10±6.74 | 0.323 | 43.79±6.90 | 41.31±5.89 | 0.043 |
| INR | 1.19±0.25 | 1.23±0.24 | 1.15±0.27 | 0.094 | 1.23±0.25 | 1.14±0.25 | 0.042 |
| Child-Pugh class, n (%) | 0.633 | 0.211 | |||||
| A | 62 (52.5) | 30 (48.4) | 32 (57.1) | 31 (45.6) | 31 (62.0) | ||
| B | 47 (39.8) | 27 (43.5) | 20 (35.7) | 31 (45.6) | 16 (32.0) | ||
| C | 9 (7.6) | 5 (8.1) | 4 (7.1) | 6 (8.8) | 3 (6.0) | ||
| Child-Pugh score | 6.69±1.73 | 6.89±1.81 | 6.48±1.63 | 0.206 | 6.96±1.86 | 6.34±1.49 | 0.056 |
| MELD score | 4.72±5.83 | 5.16±4.71 | 4.24±6.88 | 0.392 | 4.97±4.77 | 4.39±7.07 | 0.591 |
| APRI score | 3.13±5.13 | 3.69±6.44 | 2.50±3.01 | 0.209 | 3.58±6.18 | 2.51±3.13 | 0.261 |
| AAR score | 1.58±0.84 | 1.68±0.89 | 1.48±0.79 | 0.206 | 1.66±0.87 | 1.48±0.80 | 0.266 |
| FIB-4 score | 8.24±8.27 | 9.87±9.66 | 6.45±5.98 | 0.024 | 9.58±9.38 | 6.42±6.10 | 0.04 |
| FI score | −28.21±6.23 | −26.81±5.83 | −29.76±6.25 | 0.01 | −26.74±5.98 | −30.21±6.07 | 0.002 |
| King score | 81.27±176.82 | 101.92±231.32 | 58.40±78.43 | 0.183 | 97.82±221.78 | 58.76±80.67 | 0.237 |
AAR – AST to ALT ratio; ALB – albumin; ALP – alkaline phosphatase; ALT – alanine aminotransferase; APRI – AST to platelets ratio index; APTT – activated partial thromboplastin time; AST – aspartate aminotransferase; AUC – area under curve; BUN – blood urea nitrogen; Cr – creatinine; DBIL – direct bilirubin; FI – fibrosis index; FIB-4 – fibrosis 4 index; GGT – gamma-glutamyl transpeptidase; Hb – hemoglobin; IBIL – indirect bilirubin; INR – international normalized ratio; MELD – model for end-stage liver disease; NA – not available; PLT – platelet; PT – prothrombin time; Pts – patients; RBC – red blood cell; TBIL – total bilirubin; UGIB – upper gastrointestinal bleeding; WBC – white blood cell.