Table 3.
Subgroup analysis of patients without UGIB at Child-Pugh class A.
| Variables | Total Pts (n=62) | Moderate-large varices Pts (n=30) | No-mild varices Pts (n=32) | P value | With warices Pts (n=31) | Without varices Pts (n=31) | P value |
|---|---|---|---|---|---|---|---|
| Sex (male/female) | 33/29 | 17/13 | 16/16 | 0.599 | 17/14 | 16/15 | 0.799 |
| Age (years) | 54.61±11.50 | 55.19±11.42 | 54.06±11.74 | 0.702 | 55.09±11.24 | 54.12±11.93 | 0.741 |
| Etiology of liver diseases, n (%) | 0.159 | 0.244 | |||||
| Hepatitis B virus | 22 (35.5) | 14 (46.7) | 8 (25.0) | 14 (45.2) | 8 (25.8) | ||
| Hepatitis C virus | 3 (4.8) | 2 (6.7) | 1 (3.1) | 2 (6.5) | 1 (3.2) | ||
| Hepatitis B virus + Hepatitis C virus | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Alcohol | 11 (17.7) | 4 (13.3) | 7 (21.9) | 4 (12.9) | 7 (22.6) | ||
| Hepatitis B virus + Alcohol | 3 (4.8) | 2 (6.7) | 1 (3.1) | 2 (6.5) | 1 (3.2) | ||
| Unknown | 20 (32.3) | 6 (20.0) | 14 (43.8) | 7 (22.6) | 13 (41.9) | ||
| Others | 3 (4.8) | 2 (6.7) | 1 (3.1) | 2 (6.5) | 1 (3.2) | ||
| Ascites, n (%) | 0.947 | 1 | |||||
| No | 58 (93.5) | 28 (93.3) | 30 (93.8) | 29 (93.5) | 29 (93.5) | ||
| Mild | 4 (6.5) | 2 (6.7) | 2 (6.3) | 2 (6.5) | 2 (6.5) | ||
| Moderate to severe | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Hepatic encephalopathy, n (%) | NA | NA | |||||
| No | 62 (100) | 30 (100) | 32 (100) | 31 (100) | 31 (100) | ||
| Grade I–II | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Grade III–IV | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Varices, n (%) | NA | NA | |||||
| No | 31 (50.0) | 0 (0) | 31 (96.9) | 0 (0) | 31 (100) | ||
| Mild | 1 (1.6) | 0 (0) | 1 (3.1) | 3 (3.2) | 0 (0) | ||
| Moderate | 8 (12.9) | 8 (26.7) | 0 (0) | 8 (25.8) | 0 (0) | ||
| Severe | 22 (35.5) | 22 (73.3) | 0 (0) | 22 (71.0) | 0 (0) | ||
| Laboratory tests | |||||||
| RBC | 3.95±0.71 | 3.40±0.57 | 3.90±0.83 | 0.588 | 3.99±0.56 | 3.91±0.84 | 0.637 |
| Hb | 122.03±25.39 | 123.23±23.38 | 120.91±27.47 | 0.722 | 123.00±23.02 | 121.06±27.91 | 0.767 |
| WBC | 3.82±1.52 | 3.37±1.10 | 4.24±1.75 | 0.023 | 3.38±1.08 | 4.26±1.78 | 0.022 |
| PLT | 87.34±50.03 | 76.10±44.14 | 97.88±53.52 | 0.087 | 76.48±43.45 | 98.19±54.38 | 0.088 |
| TBIL | 19.43±9.53 | 20.66±7.61 | 18.27±11.04 | 0.327 | 20.57±7.50 | 18.29±11.22 | 0.35 |
| DBIL | 7.66±3.93 | 7.93±3.25 | 7.34±4.52 | 0.56 | 7.88±3.20 | 7.37±4.59 | 0.614 |
| IBIL | 11.72±5.90 | 12.63±4.78 | 10.87±6.75 | 0.242 | 12.53±4.74 | 10.92±6.85 | 0.287 |
| ALB | 38.68±4.62 | 38.09±4.44 | 39.23±4.79 | 0.338 | 38.12±4.37 | 39.23±4.87 | 0.347 |
| ALT | 45.19±50.60 | 46.07±48.51 | 44.38±53.25 | 0.897 | 46.00±47.70 | 44.39±54.13 | 0.901 |
| AST | 51.81±51.21 | 56.17±61.74 | 47.72±39.50 | 0.521 | 55.61±60.78 | 48.00±40.12 | 0.563 |
| ALP | 100.61±70.72 | 109.89±94.03 | 91.92±37.51 | 0.321 | 113.83±95.02 | 87.40±27.91 | 0.142 |
| GGT | 104.42±177.76 | 89.47±144.00 | 118.44±205.82 | 0.526 | 105.42±167.13 | 103.42±190.57 | 0.965 |
| BUN | 5.10±2.34 | 5.22±1.30 | 4.99±3.03 | 0.704 | 5.26±1.30 | 4.94±3.07 | 0.594 |
| Cr | 60.24±49.09 | 54.74±10.69 | 65.39±67.66 | 0.398 | 54.95±10.57 | 65.53±68.78 | 0.4 |
| PT | 14.11±1.55 | 14.51±1.62 | 13.74±1.42 | 0.05 | 14.42±1.67 | 13.81±1.39 | 0.119 |
| APTT | 40.95±5.49 | 41.21±5.67 | 40.70±5.39 | 0.718 | 41.32±5.61 | 40.58±5.43 | 0.6 |
| INR | 1.09±0.15 | 1.14±0.16 | 1.05±0.14 | 0.036 | 1.13±0.17 | 1.06±0.14 | 0.089 |
| Child-Pugh score | 5.35±0.48 | 5.33±0.48 | 5.38±0.49 | 0.737 | 5.32±0.48 | 5.39±0.50 | 0.603 |
| MELD score | 2.42±3.99 | 3.13±3.17 | 1.76±4.58 | 0.179 | 3.06±3.14 | 1.78±4.66 | 0.21 |
| APRI score | 2.29±2.75 | 2.44±2.73 | 2.15±2.80 | 0.68 | 2.40±2.69 | 2.18±2.84 | 0.75 |
| AAR score | 1.29±0.44 | 1.29±0.36 | 1.29±0.50 | 0.979 | 1.28±0.36 | 1.30±0.50 | 0.835 |
| FIB-4 score | 6.26±5.03 | 6.84±4.46 | 5.71±5.53 | 0.382 | 6.73±4.42 | 5.79±5.61 | 0.462 |
| FI score | −31.55±4.68 | −30.85±4.44 | −32.20±4.87 | 0.258 | −30.88±4.37 | −32.21±4.95 | 0.266 |
| King score | 51.28±70.67 | 57.61±75.38 | 45.34±66.61 | 0.499 | 56.39±74.42 | 44.17±67.55 | 0.573 |
AAR – AST to ALT ratio; ALB – albumin; ALP – alkaline phosphatase; ALT – alanine aminotransferase; APRI – AST to platelets ratio index; APTT – activated partial thromboplastin time; AST – aspartate aminotransferase; AUC – area under curve; BUN – blood urea nitrogen; Cr – creatinine; DBIL – direct bilirubin; FI – fibrosis index; FIB-4 – fibrosis 4 index; GGT – gamma-glutamyl transpeptidase; Hb – hemoglobin; IBIL – indirect bilirubin; INR – international normalized ratio; MELD – model for end-stage liver disease; NA – not available; PLT – platelet; PT – prothrombin time; Pts – patients; RBC – red blood cell; TBIL – total bilirubin; UGIB – upper gastrointestinal bleeding; WBC – white blood cell.