Table 4.
Subgroup analysis patients without UGIB at Child-Pugh class B and C.
| Variables | Total Pts (n=56) | Moderate-large varices Pts (n=32) | No-mild varices Pts (n=24) | P value | With varices Pts (n=37) | Without varices Pts (n=19) | P value |
|---|---|---|---|---|---|---|---|
| Sex (male/female) | 36/20 | 19/13 | 17/7 | 0.376 | 21/16 | 15/4 | 0.101 |
| Age (years) | 55.63±10.55 | 56.55±10.45 | 54.41±10.78 | 0.457 | 54.74±12.02 | 57.36±6.79 | 0.383 |
| Etiology of liver diseases, n (%) | 0.355 | 0.617 | |||||
| Hepatitis B virus | 6 (10.7) | 5 (15.6) | 1 (4.2) | 5 (13.5) | 1 (5.3) | ||
| Hepatitis C virus | 5 (8.9) | 3 (9.4) | 2 (8.3) | 4 (10.8) | 1 (5.3) | ||
| Hepatitis B virus + Hepatitis C virus | 1 (1.8) | 1 (3.1) | 0 (0) | 1 (2.7) | 0 (0) | ||
| Alcohol | 19 (33.9) | 9 (28.1) | 10 (41.7) | 10 (27.0) | 9 (47.4) | ||
| Hepatitis B virus + Alcohol | 5 (8.9) | 3 (9.4) | 2 (8.3) | 3 (8.1) | 2 (10.5) | ||
| Unknown | 13 (23.2) | 5 (15.6) | 8 (33.3) | 8 (21.6) | 5 (26.3) | ||
| Others | 7 (12.5) | 6 (18.8) | 1 (4.2) | 6 (16.2) | 1 (5.3) | ||
| Ascites, n (%) | 0.763 | 0.436 | |||||
| No | 11 (19.6) | 6 (18.8) | 5 (20.8) | 6 (16.2) | 5 (26.3) | ||
| Mild | 14 (25.0) | 7 (21.9) | 7 (29.2) | 11 (29.7) | 3 (15.8) | ||
| Moderate to severe | 31 (55.4) | 19 (59.4) | 12 (50.0) | 20 (54.1) | 11 (57.9) | ||
| Hepatic encephalopathy, n (%) | 0.382 | 0.47 | |||||
| No | 55 (98.2) | 31 (96.9) | 24 (100) | 36 (97.3) | 19 (100) | ||
| Grade I–II | 1 (1.8) | 1 (3.1) | 0 (0) | 1 (2.7) | 0 (0) | ||
| Grade III–IV | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Varices, n (%) | NA | NA | |||||
| No | 19 (33.9) | 0 (0) | 19 (79.2) | 0 (0) | 19 (100) | ||
| Mild | 5 (8.9) | 0 (0) | 5 (20.8) | 5 (13.5) | 0 (0) | ||
| Moderate | 12 (21.4) | 12 (37.5) | 0 (0) | 12 (32.4) | 0 (0) | ||
| Severe | 20 (35.7) | 20 (62.5) | 0 (0) | 20 (54.1) | 0 (0) | ||
| Laboratory tests | |||||||
| RBC | 3.47±0.70 | 3.38±0.68 | 3.57±0.72 | 0.321 | 3.41±0.66 | 3.57±0.76 | 0.418 |
| Hb | 110.79±25.26 | 108.16±25.74 | 114.29±24.72 | 0.373 | 108.51±25.02 | 115.21±25.83 | 0.352 |
| WBC | 4.76±2.84 | 4.48±3.08 | 5.13±2.50 | 0.398 | 4.36±2.97 | 5.53±2.48 | 0.147 |
| PLT | 94.46±68.76 | 77.69±57.08 | 116.83±77.46 | 0.034 | 77.00±56.17 | 128.47±79.29 | 0.007 |
| TBIL | 43.86±49.60 | 39.50±25.78 | 49.66±70.19 | 0.453 | 38.18±25.02 | 54.90±77.92 | 0.236 |
| DBIL | 26.93±40.35 | 22.41±21.48 | 32.97±56.61 | 0.337 | 21.58±20.53 | 37.37±62.91 | 0.168 |
| IBIL | 16.93±14.50 | 17.10±10.37 | 16.71±15.11 | 0.911 | 16.61±10.16 | 17.56±16.44 | 0.789 |
| ALB | 31.57±5.42 | 30.24±4.23 | 33.34±6.35 | 0.033 | 30.50±4.86 | 33.65±5.96 | 0.038 |
| ALT | 65.91±170.15 | 45.84±45.67 | 92.67±255.18 | 0.313 | 43.86±42.84 | 108.84±286.09 | 0.178 |
| AST | 91.02±136.48 | 91.59±134.20 | 90.25±142.36 | 0.971 | 86.00±125.87 | 100.79±158.35 | 0.705 |
| ALP | 142.19±98.51 | 138.69±104.10 | 146.84±92.52 | 0.762 | 137.44±105.29 | 151.43±85.69 | 0.619 |
| GGT | 185.80±260.43 | 185.16±299.19 | 186.67±203.82 | 0.983 | 172.89±282.97 | 210.95±214.69 | 0.609 |
| BUN | 6.18±4.14 | 5.50±2.78 | 7.08±5.39 | 0.161 | 5.46±2.62 | 7.57±5.96 | 0.072 |
| Cr | 69.96±60.95 | 61.72±36.15 | 80.93±83.08 | 0.247 | 59.35±34.22 | 90.62±91.26 | 0.069 |
| PT | 16.12±2.74 | 16.27±2.36 | 15.92±3.22 | 0.638 | 16.31±2.51 | 15.75±3.18 | 0.479 |
| APTT | 44.72±7.15 | 45.28±6.57 | 43.98±7.94 | 0.506 | 45.85±7.26 | 42.51±6.55 | 0.097 |
| INR | 1.30±0.29 | 1.32±0.27 | 1.28±0.33 | 0.651 | 1.32±0.28 | 1.27±0.33 | 0.489 |
| Child-Pugh score | 8.18±1.36 | 8.34±1.31 | 7.96±1.43 | 0.299 | 8.32±1.42 | 7.89±1.24 | 0.268 |
| MELD score | 7.27±6.49 | 7.07±5.15 | 7.54±8.06 | 0.79 | 6.57±5.32 | 8.63±8.32 | 0.265 |
| APRI score | 4.05±6.77 | 4.86±8.48 | 2.97±3.28 | 0.305 | 4.57±7.93 | 3.04±3.57 | 0.429 |
| AAR score | 1.90±1.05 | 2.03±1.08 | 1.73±1.01 | 0.286 | 1.97±1.04 | 1.77±1.09 | 0.502 |
| FIB-4 score | 10.44±10.40 | 12.70±12.16 | 7.42±6.53 | 0.06 | 11.97±11.60 | 7.46±6.87 | 0.126 |
| FI score | −24.51±5.65 | −23.02±4.23 | −26.51±6.71 | 0.021 | −23.27±4.84 | −26.94±6.43 | 0.02 |
| King score | 114.47±242.56 | 143.47±310.32 | 75.81±90.42 | 0.306 | 132.53±290.18 | 79.31±96.92 | 0.442 |
AAR – AST to ALT ratio; ALB – albumin; ALP – alkaline phosphatase; ALT – alanine aminotransferase; APRI – AST to platelets ratio index; APTT – activated partial thromboplastin time; AST – aspartate aminotransferase; AUC – area under curve; BUN – blood urea nitrogen; Cr – creatinine; DBIL – direct bilirubin; FI – fibrosis index; FIB-4 – fibrosis 4 index; GGT – gamma-glutamyl transpeptidase; Hb – hemoglobin; IBIL – indirect bilirubin; INR – international normalized ratio; MELD – model for end-stage liver disease; NA – not available; PLT – platelet; PT – prothrombin time; Pts – patients; RBC – red blood cell; TBIL – total bilirubin; UGIB – upper gastrointestinal bleeding; WBC – white blood cell.