Table 5.
Subgroup analysis of patients without UGIB or splenectomy.
| Variables | Total Pts (n=112) | Moderate-large varices Pts (n=57) | No-mild varices Pts (n=55) | P value | With varices Pts (n=62) | Without varices Pts (n=50) | P value |
|---|---|---|---|---|---|---|---|
| Sex (male/female) | 66/46 | 33/24 | 33/22 | 0.821 | 35/27 | 31/19 | 0.553 |
| Age (years) | 55.19±10.50 | 55.49±10.91 | 54.88±10.15 | 0.757 | 55.06±10.73 | 55.35±10.32 | 0.885 |
| Etiology of liver diseases, n (%) | 0.047 | 0.149 | |||||
| Hepatitis B virus | 28 (25.0) | 19 (33.3) | 9 (16.4) | 19 (30.6) | 9 (18.0) | ||
| Hepatitis C virus | 6 (5.4) | 3 (5.3) | 3 (5.5) | 4 (6.5) | 2 (4.0) | ||
| Hepatitis B virus + Hepatitis C virus | 1 (0.9) | 1 (1.8) | 0 (0) | 1 (1.6) | 0 (0) | ||
| Alcohol | 28 (25.0) | 11 (19.3) | 17 (30.9) | 12 (19.4) | 16 (32.0) | ||
| Hepatitis B virus + Alcohol | 7 (6.3) | 4 (7.0) | 3 (5.5) | 4 (6.5) | 3 (6.0) | ||
| Unknown | 32 (28.6) | 11 (19.3) | 21 (38.2) | 14 (22.6) | 18 (36.0) | ||
| Others | 10 (9.0) | 8 (14.0) | 2 (3.6) | 8 (12.9) | 2 (4.0) | ||
| Ascites, n (%) | 0.495 | 0.202 | |||||
| No | 66 (58.9) | 31 (54.4) | 35 (63.6) | 32 (51.6) | 34 (68.0) | ||
| Mild | 16 (14.3) | 8 (14.0) | 8 (14.5) | 11 (17.7) | 5 (10.0) | ||
| Moderate to severe | 30 (26.8) | 18 (31.6) | 12 (21.8) | 19 (30.6) | 11 (22.0) | ||
| Hepatic encephalopathy, n (%) | 0.324 | 0.367 | |||||
| No | 111 (99.1) | 56 (98.2) | 55 (100) | 61 (98.4) | 50 (100) | ||
| Grade I–II | 1 (0.9) | 1 (1.8) | 0 (0) | 1 (1.6) | 0 (0) | ||
| Grade III–IV | 0 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Varices, n (%) | NA | NA | |||||
| No | 50 (44.6) | 0 (0) | 50 (90.9) | 0 (0) | 50 (100) | ||
| Mild | 5 (4.5) | 0 (0) | 5 (9.1) | 5 (8.1) | 0 (0) | ||
| Moderate | 17 (15.2) | 17 (29.8) | 0 (0) | 17 (27.4) | 0 (0) | ||
| Severe | 40 (35.7) | 40 (70.2) | 0 (0) | 40 (64.5) | 0 (0) | ||
| Laboratory tests | |||||||
| RBC | 3,72±0.75 | 3.67±0.70 | 3.77±0.80 | 0.511 | 3.67±0.69 | 3.78±0.82 | 0.452 |
| Hb | 116.52±25.46 | 114.95±24.51 | 118.15±26.54 | 0.509 | 114.65±24.19 | 118.84±27.03 | 0.388 |
| WBC | 4.22±2.32 | 3.88±2.47 | 4.58±2.12 | 0.111 | 3.80±2.39 | 4.74±2.14 | 0.032 |
| PLT | 86.51±56.75 | 68.74±40.66 | 104.93±65.01 | 0.001 | 67.81±39.71 | 109.70±65.88 | ﹤0.01 |
| TBIL | 31.39±37.63 | 30.93±21.79 | 31.87±49.17 | 0.895 | 30.74±21.52 | 32.20±51.28 | 0.839 |
| DBIL | 17.21±30.15 | 15.98±17.66 | 18.49±39.27 | 0.662 | 15.95±17.29 | 18.77±41.03 | 0.625 |
| IBIL | 14.14±10.01 | 14.89±8.38 | 13.36±11.49 | 0.42 | 14.70±8.39 | 13.44±11.78 | 0.509 |
| ALB | 35.33±6.03 | 33.82±5.63 | 36.89±6.09 | 0.007 | 33.89±5.78 | 37.11±5.92 | 0.005 |
| ALT | 54.96±125.56 | 44.88±46.45 | 65.42±173.05 | 0.389 | 43.74±44.76 | 68.88±181.27 | 0.294 |
| AST | 70.61±104.86 | 75.81±110.16 | 62.22±99.78 | 0.595 | 72.66±106.15 | 68.06±104.24 | 0.819 |
| ALP | 120.29±85.90 | 129.11±102.22 | 111.15±64.53 | 0.271 | 127.19±99.89 | 111.73±64.50 | 0.346 |
| GGT | 145.40±228.06 | 146.47±249.14 | 144.29±206.25 | 0.96 | 146.31±246.88 | 144.28±204.81 | 0.963 |
| BUN | 5.62±3.42 | 5.40±2.24 | 5.86±4.33 | 0.476 | 5.37±2.16 | 5.94±4.52 | 0.379 |
| Cr | 65.27±56.43 | 58.48±28.12 | 72.31±75.01 | 0.196 | 57.37±27.32 | 75.06±78.15 | 0.099 |
| PT | 15.03±2.43 | 15.37±2.23 | 14.68±2.60 | 0.136 | 15.42±2.39 | 14.55±2.41 | 0.057 |
| APTT | 42.46±6.48 | 42.97±6.26 | 41.97±6.72 | 0.416 | 43.41±6.82 | 41.31±5.89 | 0.088 |
| INR | 1.19±0.25 | 1.22±0.23 | 1.15±0.27 | 0.153 | 1.23±0.25 | 1.14±0.25 | 0.06 |
| Child-Pugh class, n (%) | 0.478 | 0.206 | |||||
| A | 59 (52.7) | 27 (47.4) | 32 (58.2) | 28 (45.2) | 31 (62.0) | ||
| B | 45 (40.2) | 26 (45.6) | 19 (34.5) | 29 (46.8) | 16 (32.0) | ||
| C | 8 (7.1) | 4 (7.0) | 4 (7.3) | 5 (8.1) | 3 (6.0) | ||
| Child-Pugh score | 6.69±1.72 | 6.91±1.79 | 6.45±1.63 | 0.16 | 6.97±1.85 | 6.34±1.49 | 0.054 |
| MELD score | 4.69±5.98 | 5.13±4.90 | 4.24±6.94 | 0.432 | 4.94±4.97 | 4.39±7.07 | 0.627 |
| APRI score | 3.22±5.24 | 3.90±6.68 | 2.51±3.04 | 0.163 | 3.79±6.43 | 2.51±3.13 | 0.198 |
| AAR score | 1.59±0.85 | 1.72±0.91 | 1.46±0.78 | 0.119 | 1.68±0.89 | 1.48±0.80 | 0.219 |
| FIB-4 score | 8.51±8.38 | 10.42±9.85 | 6.53±6.00 | 0.014 | 10.19±9.57 | 6.42±6.10 | 0.017 |
| FI score | −28.20±6.15 | −26.51±5.59 | −29.94±6.26 | 0.003 | −26.57±5.76 | −30.21±6.07 | 0.002 |
| King score | 83.77±180.99 | 107.44±240.35 | 59.24±78.90 | 0.16 | 103.95±231.20 | 58.76±80.67 | 0.19 |
AAR – AST to ALT ratio; ALB – albumin; ALP – alkaline phosphatase; ALT – alanine aminotransferase; APRI – AST to platelets ratio index; APTT – activated partial thromboplastin time; AST – aspartate aminotransferase; AUC – area under curve; BUN – blood urea nitrogen; Cr – creatinine; DBIL – direct bilirubin; FI – fibrosis index; FIB-4 – fibrosis 4 index; GGT – gamma-glutamyl transpeptidase; Hb – hemoglobin; IBIL – indirect bilirubin; INR – international normalized ratio; MELD – model for end-stage liver disease; NA – not available; PLT – platelet; PT – prothrombin time; Pts – patients; RBC – red blood cell; TBIL – total bilirubin; UGIB – upper gastrointestinal bleeding; WBC – white blood cell.