Table 4.

Results for the thirteen chromosomal candidate regions using joint linkage and association analysis in the entire sample of 282 LOAD families

Chr	SNP	bp	band	67 LOAD fams		215 LOAD fams		282 LOAD fams
				Pjoint		Pjoint		Pjoint
				Dom	Rec	Dom	Rec	Dom	Rec
2	rs4665809	26,251,361	2p23.3	1.2 × 10−4	0.001	0.474	0.420	2.8 x10−4	0.001
2	rs10173959	31,028,945	2p23.1	5.9 × 10−5	0.005	0.998	0.881	0.001	0.013
2	rs2071048	138,721,597	2q22.1	1.7 × 10−4	0.151	0.126	0.111	0.003	0.039
3	rs1709965	106,659,501	3q13.12	2.9 × 10−5	0.003	0.924	0.326	0.005	0.027
3	rs6438213	114,329,961	3q13.31	7.0 × 10−6	3.7 × 10−5	0.759	0.779	2.7 x10−4	0.002
5	rs7700370	33,702,830	5p13.3	0.001	0.033	0.695	0.596	0.014	0.042
6	rs9390610	149,113,186	6q25.1	4.4 × 10−4	0.032	0.818	0.190	0.149	0.055
6	rs9390611	149,114,811	6q25.1	0.001	0.001	0.650	0.719	0.019	0.022
6	rs11966489	157,414,029	6q25.3	1.5 × 10−4	0.001	0.358	0.364	0.009	0.043
7	rs2240401	30,673,345	7p14.3	7.0 × 10−5	4.3 × 10−4	0.096	0.049	2.8 ×10−5	7.4 ×10−5
7	rs10255835	31,044,646	7p14.3	3.0 × 10−5	5.0 × 10−6	0.189	0.239	3 ×10−5	1.2 ×10−5
7	rs218097	31,497,237	7p14.3	0.001	0.016	0.885	0.804	0.016	0.095
7	rs6651030	156,876,217	7q36.3	2.0 x10−4	0.013	0.559	0.680	0.013	0.037
9	rs3739553	129,984,107	9q33.3	4.9 × 10−4	0.005	0.359	0.584	0.005	0.034
10	rs12360009	14,333,240	10p13	3.1 × 10−4	0.001	0.151	0.222	7.9 x10−5	3.4 ×10−4
11	rs2232932	61,957,137	11q12.3	3.1 × 10−5	1.9 × 10−4	0.046	0.060	6.6 x10−6	3.9 ×10−5

P_joint correspond to the P-value of the joint linkage and association analysis. Regions with significant SNPs after Bonferroni’s adjustment (P ≤ 0.003) under both models are shown in bold and italics.