Table 3.
Comparison of the top performing corneal response variables and geometric measurements for distinguishing Marfan syndrome eyes from controls.
| Group | Variable | AUROC | P value | Confidence Interval |
Cutoff | Sensitivity (%) | Specificity (%) | PPV | NPV |
|---|---|---|---|---|---|---|---|---|---|
| 1: Applanation Signal Intensity | Concavity Min | 0.80 | 0.008 | (0.65, 0.95) | 51.01 | 54 | 96 | 88 | 79 |
| Concavity Mean | 0.79 | 0.02 | (0.63, 0.95) | 163.33 | 85 | 67 | 58 | 89 | |
| 2: Pressure | CRF (mmHg) | 0.74 | 0.02 | (0.57, 0.92) | 10.30 | 85 | 63 | 53 | 88 |
| CH (mmHg) | 0.77 | 0.01 | (0.60, 0.94) | 10.90 | 77 | 71 | 59 | 85 | |
| P1 (mmHg) | 0.76 | 0.01 | (0.60, 0.93) | 51.80 | 85 | 67 | 58 | 89 | |
| P2 (mmHg) | 0.75 | 0.01 | (0.58, 0.92) | 41.01 | 85 | 63 | 55 | 88 | |
| P1P2Avg (mmHg) | 0.76 | 0.01 | (0.59, 0.92) | 46.35 | 85 | 67 | 58 | 89 | |
| 5: Pressure and Applanation Intensity | HLA | 0.72 | 0.03 | (0.54, 0.89) | 26213.8 4 | 54 | 88 | 70 | 78 |
| Geometric measurements | Corneal Curvature (Km, diopter) | 0.72 | 0.04 | (0.54, 0.90) | 41.40 D | 62 | 79 | 62 | 79 |
Abbreviations: CH = corneal hysteresis; CRF = corneal resistance factor; HLA = hysteresis loop area; AUROC = area under the receiver operating characteristic curve; PPV = positive predictive value; NPV = negative predictive value