Table 2.

Protein Expression in Collateral Dependent Myocardium

Targets	HCC	LCI	HCI	p value
ANGIOGENESIS PROTEINS
VEGF	1 ± 0.366	1.96 ± 0.819	1.30 ± 0.245	0.02*
VEGF R1	1 ± 0..208	1.71 ± 0.380	1.26 ± 0.289	0.0003*‡
VEGF R2	1 ± 0.249	2.42 ± 0.839	1.19 ± 0.244	0.0003*‡
VE Cadherin	1 ± 0.258	1.23 ± 0.172	1.77 ± 0.576	0.58
iNOS	1 ± 0.379	1.01 ± 0.344	1.71 ± 1.390	0.21
ERK	1 ± 0.322	1.41 ± 0.508	1.33 ± 0.794	0.32
pERK	1 ± 0.469	1.23 ± 0.594	1.25 ± 0.538	0.54
Endostatin	1 ± 0.401	1.02 ± 0.278	0.97 ± 0.484	0.99
Angiopoietin 1	1 ± 0.710	1.16 ± 0.599	0.90 ± 0.479	0.67
STRUCTURAL PROTEINS
RhoA	1 ± 0.198	1.08 ± 0.305	1.03 ± 0.226	0.21
Tau	1 ± 0.342	1.08 ± 0.373	1.06 ± 0.372	0.91
Talin	1 ± 0.115	1.71 ± 0.179	1.79 ± 0.496	0.0002*†
Paxillin	1 ± 0.386	0.91 ± 0.309	1.47 ± 0.296	0.11
Vinculin	1 ± 1.179	0.65 ± 0.424	0.71 ± 0.342	0.60

Protein expression listed as fold change ± SD compared to HCC. One way analysis of variance performed to determine p value. Bonferroni multiple comparison tests were performed:

^*indicates significant difference between HCC and LCI group.

^†indicates significant difference between HCC and HCI.

^‡indicates significant difference between LCI and HCI group. HCC: High Cholesterol Control; LCI: Low Dose Calpain Inhibitor; HCI: High Dose Calpain Inhibitor