Table 1.
Clinical, endoscopic, and histologic characteristics of the controls and EoE cases
| Non-EoE controls (n = 144) | EoE cases (n = 67) | p* | |
|---|---|---|---|
| Age at diagnosis (mean ± SD) | 51.6 ± 13.5 | 38.0 ± 13.0 | < 0.001 |
| Male (n, %) | 54 (38) | 39 (58) | 0.005 |
| White (n, %) | 118 (82) | 63 (94) | 0.02 |
| Symptoms/EGD indication (n, %) | |||
| Dysphagia | 108 (75) | 65 (97) | < 0.001 |
| Heartburn | 103 (72) | 12 (18) | < 0.001 |
| Abdominal pain | 9 (6) | 7 (10) | 0.28 |
| Nausea/vomiting | 12 (8) | 1 (1) | 0.05 |
| Atopic disorders (n, %) | |||
| Asthma | 33 (23) | 20 (30) | 0.28 |
| Atopic dermatitis | 10 (7) | 5 (7) | 0.89 |
| Allergic rhinitis/sinusitis | 69 (48) | 44 (66) | 0.02 |
| Food allergies | 21 (15) | 30 (45) | < 0.001 |
| Any atopic disease | 83 (58) | 50 (75) | 0.02 |
| EGD findings (n, %) | |||
| Normal | 23 (16) | 3 (4) | 0.02 |
| Rings | 14 (10) | 52 (78) | < 0.001 |
| Stricture | 26 (18) | 16 (24) | 0.32 |
| Narrowing | 5 (3) | 20 (30) | < 0.001 |
| Furrows | 9 (6) | 60 (90) | < 0.001 |
| Crêpe-paper | 3 (2) | 4 (6) | 0.14 |
| White plaques/exudates | 4 (3) | 33 (49) | < 0.001 |
| Decreased vascularity/edema | 5 (3) | 42 (63) | < 0.001 |
| Dilation performed | 44 (31) | 21 (31) | 0.91 |
| Baseline maximum eosinophil count (mean ± SD) | 2.5 ± 6.3 | 149.9 ± 124.2 | < 0.001 |
| Treatment (n, %) | |||
| Topical steroids | -- | 65 (96) | -- |
| Diet elimination | -- | 3 (4) | -- |
| Post-treatment eosinophil count (mean ± SD) | -- | 50.3 ± 84.2 | -- |
| Response with < 15 eos/hpf (n, %) | -- | 38 (57) | -- |
*
Proportions are compared with chi-square; means are compared with a two-sample t-test