Table 4.

Association between etiologic risk factors and risk of HCC in absence of cirrhosis – Results of logistic regression analysis examining two models (model 1 contains NAFLD, model 2 contains metabolic syndrome)

	Model 1			Model 2
Variable	n	Unadjusted OR (95% CI)	* Adjusted OR (95% CI)	Variable	Unadjusted OR (95% CI)	* Adjusted OR (95% CI)
Etiology				Etiology
HCV	952	1.0	1.0	HCV	1.0	1.0
NAFLD	107	5.4 (3.4–8.5)	3.9 (2.1–7.3)	Metabolic syndrome	5.0 (3.1–7.8)	3.4 (1.9–6.4)
Alcohol abuse	280	2.6 (1.8–3.8)	2.5 (1.6–3.9)	Alcohol abuse	2.6 (1.8–3.8)	2.5 (1.5–3.9)
HBV	15	1.6 (0.4–7.1)	1.3 (0.2–7.2)	HBV	1.6 (0.4–7.1)	1.3 (0.2–7.2)
Idiopathic	41	4.7 (2.4–9.5)	3.6 (1.6–8.3)	Idiopathic	6.0 (3.0–11.9)	5.1 (2.2–11.7)
Age	139 5		1.0 (1.0–1.1)			1.0 (1.0–1.1)
Race
White	829		1.0			1.0
Black	362		2.2 (1.5–3.4)			2.2 (1.5–3.4)
Hispanic	172		0.4 (0.2–0.7)			0.4 (0.2–0.7)
Others	32		0.9 (0.2–3.4)			0.9 (0.2–3.4)
BCLC Stage
A	188		1.0			1.0
B	328		2.9 (1.4–5.8)			2.9 (1.4–5.9)
C	527		2.5 (1.3–5.2)			2.6 (1.3–5.2)
D	246		1.2 (0.5–2.9)			1.2 (0.5–2.9)
Unknown	106		2.5 (1.0–6.0)			2.5 (1.0–2.9)
MELD score
< 10	551		1.0			1.0
10–19.9	641		0.2 (0.1–0.3)			0.2 (0.1–0.3)
20+	73		0.1 (0.0–0.5)			0.1 (0.0–0.5)
Unknown	130		0.7 (0.4–1.2)			0.7 (0.4–1.3)
AFP
<20	516		1.0			1.0
20+	780		0.8 (0.5–1.2)			0.8 (0.5–1.2)
Unknown	99		1.6 (0.9–2.8)			1.6 (0.9–2.8)
PVT
Absent	111 3		1.0			1.0
Present	241		0.6 (0.3–1.1)			0.6 (0.3–1.1)
Unknown	41		2.3 (1.1–4.9)

^*Adjusted for age, race, BCLC stage, MELD score, AFP and portal vein thrombus