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. 2015 Jul 24;44:222–233. doi: 10.1007/s10439-015-1393-5

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Workflow for integrating imaging, gait and cartilage quality data into a multiscale subject-specific model of human knee cartilage. For further discussion on each component, see host-mesh fitting,19 EMG-informed muscle forces in gait,35 knee cartilage stress–strain,7,8 and poroelastic models of cartilage.49,59,65 We argue that tissue-level metrics of cartilage consolidation and fluid exudation will have a stronger association with cartilage loss and defect enlargement than risk factors used in previous studies.