Table 2.
Number of subjects with primary NRTI and NNRTI drug resistance mutations detected at low frequency (≥2% to 20%) in baseline samples by deep sequencing.
RPV/FTC/TDF RAP N = 24 | EFV/FTC/TDF RAP N = 9 | Non-RAP Controls N = 118 | Total N = 151 | |
---|---|---|---|---|
No mutations, n (%) | 24 (100%) | 9 (100%) | 108 (91.5%) | 141 (93.4%) |
Any NRTI-R a or NNRTI-R b n (%) | 0 | 0 | 10 (8.5%) | 10 (6.6%) |
Any NRTI-R, n (%) | 0 | 0 | 3 (2.5%) | 3 (2.0%) |
Any NNRTI-R, n (%) | 0 | 0 | 7 (5.9%) | 7 (4.6%) |
a Primary nucleoside/nucleotide reverse transcriptase inhibitor resistance (NRTI-R) mutations are M41L, K65N/R, D67N, T69 insertion/deletion, K70E/R, L74V/I, Y115F, Q151M, M184I/V, L210W, T215Y/F, and K219E/Q/N/R in RT; b Primary non-nucleoside reverse transcriptase inhibitor resistance (NNRTI-R) mutations are L100I, K101E/P, K103N/S, V106A/M, V108I, E138A/G/K/Q/R, V179L, Y181C/I/V, Y188C/H/L, G190A/E/Q/S, H221Y, P225H, F227C, and M230I/L in RT.