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. 2015 Dec 18;7(12):6716–6729. doi: 10.3390/v7122968

Figure 1.

Figure 1

The HCV genome encodes a single open reading frame flanked by 5’ and 3’ untranslated regions (UTR). Cleavage of this polyprotein by host endopeptidases (for structural proteins) and viral non-structural protein NS3/4A results in producing structural proteins core (C), Envelope proteins 1 and 2 (E1, E2), and non-structural proteins p7, NS2, NS3, NS4A, NS4B, NS4A, and NS5B. Enzymatic function of non-structural proteins has been the basis of DAAs (outlined in red). These can be overcome by common breakthrough mutations (circled and highlighted).