Table 1.
Common RAVs; resistance and prevalence.
| Drug Class | Example | Common RAV | Resistance | Prevalence |
|---|---|---|---|---|
| NS3/4A inhibitor | telaprevir | V36M | low | <1% |
| boceprevir | T54S/A | low | 2%–3% | |
| simeprevir | V55A | low | 0.4%–3% | |
| asunaprevir | Q80K | low | 0.5%–75% | |
| faldaprevir | R155K | high | <1% | |
| NS5A inhibitor | daclatasvir | M28 | high | 0.5%–4% |
| ombitasvir | Q30 | high | 0.3%–1.3% (geno 1) 50%–100% (geno 3,4) | |
| ledipasvir | L31V | high | 0.9%–6.3% (geno 1) 74%–100%(geno 2,4) | |
| Y93H | high | 1.5%–14% | ||
| NS5B NPI | sofosbuvir | L159F | n.d. | 5.2% |
| V321A | n.d. | 2.2% | ||
| S282R | low | 0.4% | ||
| NS5B NNPI | dasabuvir | C316N | low | 11%–36% |