Table 2.

Fold induction of modulated genes in mice cortex.

	Control		Treatment
	Male	Female	Male	Female	F Value			p Value
	Fold Change	Fold Change	Fold Change	Fold Change	Treatment	Sex	Interaction	Treatment	Sex	Interaction
SNAP29	1.03 ± 0.10	1.02 ± 0.12	0.95 ± 0.11	0.62±0.14 *,#	24.64	12.36	10.95 &	<0.0001	0.0022	0.0035
UFD1L	1.01 ± 0.07	1.02 ± 0.06	0.61 ± 0.08 *	0.65±0.08 *	167.00	0.7042	0.2535	<0.0001	0.4113	0.6201
ZDHHC8	1.04 ± 0.05	1.05 ± 0.07	0.95 ± 0.07 *	0.58±0.06 *,#	131.40	41.09	46.23 &	<0.0001	<0.0001	<0.0001
PDLIM5	1.01 ± 0.08	1.05 ± 0.10	0.71 ± 0.10 *	0.82±0.14 *	36.64	2.935	0.639	<0.0001	0.1022	0.4334
HSPA1A	1.06 ± 0.10	0.99 ± 0.07	0.54 ± 0.11 *	0.56±0.09 *	154.30	0.4273	1.385	<0.0001	0.5207	0.2531
PTEN	0.99 ± 0.08	1.03 ± 0.09	0.63 ± 0.11 *	0.67±0.12 *	75.86	0.94	0.00	<0.0001	0.3447	1.0000
GDNF	1.01 ± 0.07	0.98 ± 0.05	0.65 ± 0.06 *	0.32±0.14 *,#	204.00	25.41	17.65 &	<0.0001	<0.0001	0.0004
SOD2	0.97 ± 0.06	0.99 ± 0.08	0.67 ± 0.12 *	0.56±0.07 *	109.10	1.66	3.46	<0.0001	0.2125	0.0776
GNAS	1.01 ± 0.09	1.06 ± 0.12	0.88 ± 0.15	0.70±0.14 *,#	22.30	1.57	4.91 &	0.0001	0.2247	0.0384
NOS3	0.96 ± 0.11	1.00 ± 0.04	0.71 ± 0.08 *	0.93±0.15 #	14.42	9.52	4.56 &	0.0011	0.0058	0.0452
DLST	1.01 ± 0.04	0.97 ± 0.06	0.91 ± 0.12	0.87±0.06	10.34	1.66	0.00	0.0043	0.2130	1.0000
GRIN2A	0.97 ± 0.08	1.01 ± 0.06	1.10 ± 0.18	2.78±0.17 *,#	423.70	317.70	288.20 &	<0.0001	<0.0001	<0.0001
DGKH	1.01 ± 0.04	1.06 ± 0.09	2.14 ± 0.09 *	0.72±0.06 *,#	175.00	526.21	605.94 &	<0.0001	<0.0001	<0.0001
MT2A	1.01 ± 0.07	1.02 ± 0.15	1.98 ± 0.07 *	2.34±0.13 *,#	639.50	16.70	14.94 &	0.0010	0.0006	<0.0001
CACNA1G	1.04 ± 0.07	1.03 ± 0.06	2.77 ± 0.13 *	0.75±0.12 *,#	516.75	938.68	887.50 &	<0.0001	<0.0001	<0.0001
KCNQ	1.00 ± 0.04	0.97 ± 0.08	2.86 ± 0.10 *	0.72±0.11 *,#	317.03	621.19	609.14 &	<0.0001	<0.0001	<0.0001

* p < 0.05, compared with corresponding sex control, ^# p < 0.05, compared with male Al₂O₃ NP treated mice, ^& p < 0.05, sex and Al₂O₃ NPs treatment showed interaction effect, df = 5.