Table 3.
Metabolite | HMDB ID | Fold Change | Male Al2O3 NPs vs. Male Control | Female Al2O3 NPs vs. Male Control | |||||
---|---|---|---|---|---|---|---|---|---|
Male Al2O3 NPs | Female Control | Female Al2O3 NPs | F Value | p Value | F Value | p Value | |||
L-Serine | HMDB00187 | 1.98 | 1.03 | 4.26 # | 13.63 | 0.002 | 53.54 | <0.0001 | |
Dihydroxy acetone Phosphate | HMDB01473 | - | 0.83 | 2.97 # | 0.43 | 0.5261 | 14.9 | 0.0017 | |
Inosine | HMDB00195 | 2.05 | 1.14 | 2.61 | 12.68 | 0.0022 | 13.01 | 0.0019 | |
Prostaglandin E2 | HMDB01220 | 2.43 | 1.27 | 4.02 | 22.31 | 0.0001 | 49.69 | <0.0001 | |
Acetyl-L-Carnitine | HMDB00201 | 2.37 | 0.96 | 3.86 | 28.74 | <0.0001 | 37.21 | <0.0001 | |
Pyroglutamic Acid | HMDB00267 | 2.53 | 0.89 | 0.52 # | 32.57 | <0.0001 | 24.52 | <0.0001 | |
Riboflavin | HMDB00244 | 3.83 | 1.07 | 2.18 | 36.53 | <0.0001 | 27.73 | <0.0001 | |
Inosine 5-Monophosphate | HMDB00175 | 1.89 | 0.93 | 1.68 | 11.42 | 0.0026 | 9.52 | 0.0058 | |
l-Glutamic Acid | HMDB00148 | - | 1.08 | 0.17 # | 1.69 | 0.2125 | 103.89 | <0.0001 | |
7b-Hydroxycholesterol | HMDB06119 | 0.48 | 0.77 | - | 28.49 | <0.0001 | 0.89 | 0.4213 | |
2-Hydroxyestrone | HMDB00343 | - | 0.98 | 0.48 | 0.25 | 0.6178 | 41.25 | <0.0001 | |
Dl-Glyceraldehyde | HMDB01051 | 0.3 | 1.06 | 0.46 | 59.77 | <0.0001 | 38.56 | <0.0001 | |
Petroselinic Acid | HMDB02080 | 0.21 | 1.18 | 0.48 | 75.86 | <0.0001 | 42.59 | <0.0001 |
# p < 0.05, compared with male Al2O3 NPs treatment, df = 5.