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. 2015 Dec;3(21):334. doi: 10.3978/j.issn.2305-5839.2015.12.13

Figure 2.

Figure 2

miRNA-targeted modulation of MM-related BMM. Examples of miR mimics (miR-29b, miR-202, miR-199a, miRs-15-16) and inhibitors (miR-21) are shown together with the main cellular targets of the BMM. miR29b promotes both MM growth and inhibition of bone resorption. miR-21 inhibitors restore the physiological RANKL/OPG ratio, favoring bone apposition. miR-202 mimics interfere with BMSC-MM cells cross talk through down-regulation of BAFF. miR-199a inhibits neoangiogenesis through suppression of HIF1, which is produced under hypoxic conditions by MM cells. miRs-15-16 inhibit neoangiogenesis by targeting VEGF. BAFF, b cell activating factor; MM, multiple myeloma; BMM, bone marrow microenvironment; OPG, osteoprotegerin; BMSC, BM stromal cell; RANKL, receptor activator nuclear factor Kappa-b ligand; VEGF, vascular endothelial growth factor; HIF1, hipoxia inducible factor 1.