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Effect of boiogito on water permeability in cultured synovial cells. a Boiogito (0.25–1 mg/mL) and the aquaporin inhibitor mercuric chloride (10 μmol/L) inhibited water permeability in synovial cells (n = 8–9). b, c Sinomenium Stem, one of six boiogito constituents, decreased water permeability of the synovial cells (n = 4–5) in a dose-dependent manner (n = 4–6). Results are expressed as mean ± SE. *P < 0.05, **P < 0.01 vs. vehicle
