Table 2.
Single locus analysis of SNPs investigated.
| Pathway | Gene | SNP | MAFcontrols | MAFcases | ORhet a | ORhom a |
|---|---|---|---|---|---|---|
| Death receptor | Dr4 | rs20576 | 8 | 14 | 1.82 (1.18–2.83) | 3.27 (0.93–11.51) |
| rs6557634 | 27 | 33 | 1.61 (1.06–2.44) | 2.05 (0.90–4.70) | ||
| FAS | rs763110 | 39 | 41 | 0.94 (0.66–1.33) | 1.26 (0.78–2.02) | |
| FASL | rs2234767 | 20 | 22 | 0.99 (0.71–1.38) | 1.66 (0.70–4.12) | |
| Tumor suppressor | DCC | rs714 | 37 | 45 | 1.84 (1.29–2.63) | 1.72 (1.08–2.74) |
| rs2229080 | 32 | 24 | 0.64 (0.46–0.89) | 0.32 (0.15–0.68) | ||
| rs7504990 | 32 | 31 | 1.01 (0.72–1.40) | 0.92 (0.51–1.65) | ||
| rs4078288 | 34 | 39 | 0.98 (0.69–1.39) | 1.58 (1.01–2.49) | ||
| Prostate stem cell antigen | PSCA | rs2978974 | 32 | 30 | 0.91 (0.65–1.27) | 0.86 (0.50–1.48) |
| rs2294008 | 42 | 46 | 1.4 (0.97–2.02) | 1.25 (0.77–2.04) | ||
| Adrenergic pathway | ADRa2a | rs1800544 | 45 | 49 | 1.35 (0.92–1.97) | 1.41 (0.87–2.29) |
| ADRB3 | rs4994 | 10 | 21 | 2.58 (1.76–3.78) | 10.61 (1.38–81.92) | |
| ADRB1 | rs1801253 | 22 | 25 | 1.32 (0.95–1.84) | 1.12 (0.46–2.78) | |
| Estrogen metabolism pathway | CYP17 | rs2486758 | 26 | 27 | 1.04 (0.74–1.45) | 1.11 (0.59–2.09) |
Significant values are denoted as bold. a Adjusted for age and gender in logistic regression model; ORhet: odds ratio of heterozygote vs. common homozygote genotypes; ORhom: odds ratio of homozygote vs. common homozygote genotypes, MAF: Minor allele frequency.