Table 3.
Multifactor dimensionality reduction (MDR) analysis showing association of high-order interactions with GBC.
| No. of Risk Factors | Best Interaction Model | Testing Accuracy | # CVC | X² (p-Value) | OR (95% CI) |
|---|---|---|---|---|---|
| 1 | ADRB3rs4994 | 0.6003 | 10/10 | 28.5717 (p < 0.0001) | 2.7507 (1.8841–4.0158) |
| 2 | DCCrs2229080, ADRB3rs4994 | 0.5658 | 6/10 | 32.5889 (p < 0.0001) | 2.6238 (1.8762–3.6693) |
| 3 | DCCrs714, DCCrs2229080, ADRB3rs4994 | 0.5913 | 9/10 | 44.324 (p < 0.0001) | 3.0155 (2.1684–4.1935) |
| 4 | DCCrs714, DCCrs2229080, PSCArs2978974, ADRB3rs4994 | 0.5353 | 3/10 | 68.7203 (p < 0.0001) | 4.0443 (2.8834–5.6726) |
# The model with maximum testing accuracy and maximum CVC cross was considered as the best model; CVC: cross-validation consistency.