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. 2015 Nov 25;16(12):28077–28086. doi: 10.3390/ijms161226083

Figure 2.

Figure 2

MCLR restored hippocampal LTP inhibition in MCLR-treated rats. (A) An ideographic electrophysiology recording with stimulating electrode and recording electrode placed in the Schaffer collaterals and the stratum radiatum layer of the CA1 region, respectively; (B) Representative traces of fEPSP before and after HFS; (C) MCLR impaired the magnitude of LTP, reflected as a decrease in the average potentiation of fEPSP in 60 min after LTP induction; (D) Histograms indicated administration of TUDCA during MCLR treatment rescued the impaired LTP induced by MCLR. * p < 0.05 compared to control, # p < 0.05 compared to MCLR alone, One-way ANOVA (n = 15 for control group, n = 13 for MCLR group, n = 13 for MCLR + TUDCA group and n = 14 for TUDCA group) followed by the Duncan multiple group comparison. Values represent mean ± SEM.