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. 2015 Nov 26;16(12):28180–28193. doi: 10.3390/ijms161226093

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Knockdown of PPARγ by its specific siRNA alleviated the inhibitory effects of evodiamine on PDGF-BB-stimulated VSMC migration. (A) Knockdown efficiency of siRNA tested by Western blot; (B,C) Quantification of VSMC migration. VSMCs were transfected with scrambled siRNA (negative control, or NC) or siRNA against PPARγ (siPPARγ). 24 h after transfection, cells were pretreated with 0.5 μM evodiamine for 6 h and then stimulated with 10 ng/mL PDGF-BB for 24 h (wound healing assay, B) or 6 h (transwell assay, C). In Panel C, blue color indicates cell nuclei stained with DAPI. Evo, evodiamine. Data are represented as mean values ± SD of three independently prepared samples each with five measurements. ** p < 0.01 compared with the control group; ^## p < 0.01 compared with the PDGF-BB-stimulated group; ^$$ p < 0.01 compared with the group treated with both evodiamine and PDGF-BB.