Table 1.

Experimental studies.

Authors	Year	Study Design	Animal	Citicoline Concentration	Citicoline Administration	Outcomes
Rejdak R et al. [62]	2002	case-control	Albino rabbits	50 mg/kg/twice day	Intraperitoneal injection	Retinal catecholamine levels
Park CH et al. [65]	2005	case-control	Spraue-Dawley rats	50 mg·kg−1	Intraperitoneal injection	Thickness of retinal layers and expression of ChAT and TH
Schuettauf F et al. [64]	2006	case-control	Rats	1 g/kg/daily and 300 mg/kg/daily	Intraperitomeal injection	Retinal ganglion cells density and expression of the antiapoptotic protein Bcl-2
Oshitari T et al. [63].	2010	case-control	Cultures from Spraue-Dawley rats	1 μM	Added to high glucose medium in retinal culture	Apoptosis evaluation by TUNEL assay and Caspase-3 and Caspase-9 activity
Matteucci A et al. [66].	2014	case-control	Cultures from embryonic rat retina	10, 100 and 1000 μM	Treated for 96 h and 24 h before glutamate-induced excitotoxic insult and high glucose-promoted neuronal cell damage	Apoptosis evaluation by TUNEL assay and caspase activation

Summary of experimental studies evaluating the effect of citicoline on retinal ganglion cells survival.