Table 1.
Pathway analysis of the differentially expressed genes by using the KEGG database.
| Pathway Name | p-Value | Hit | Total | Percent |
|---|---|---|---|---|
| Metabolism correlation | ||||
| Alanine aspartate and glutamate metabolism * | 0.0101 | 6 | 34 | 17.65% |
| alpha-Linolenic acid metabolism | 0.132 | 4 | 20 | 20% |
| Amino sugar and nucleotide sugar metabolism * | 0.046 | 5 | 49 | 10.2% |
| Arachidonic acid metabolism | 0.081 | 12 | 56 | 21.43% |
| Arginine and proline metabolism ** | 0.0096 | 5 | 26 | 19.23% |
| Ascorbate and aldarate metabolism | 0.109 | 5 | 26 | 19.23% |
| Fatty acid metabolism * | 0.046 | 20 | 50 | 40% |
| Histidine metabolism | 0.134 | 5 | 28 | 17.86% |
| Inositol phosphate metabolism * | 0.027 | 17 | 57 | 29.8% |
| Fat digestion and absorption * | 0.024 | 16 | 45 | 35% |
| beta-Alanine metabolism ** | 0.0082 | 8 | 25 | 29% |
| Linoleic acid metabolism * | 0.023 | 8 | 46 | 17.39% |
| Disease association | ||||
| Type I diabetes mellitus ** | 0.000 | 21 | 63 | 33.3% |
| Olfactory transduction ** | 0.0 | 395 | 1041 | 35% |
| Graft-versus-host disease ** | 0.0 | 19 | 58 | 32.76% |
| Parkinson’s disease | 0.9 | 9 | 151 | 5.98% |
| Chagas disease * | 0.0324 | 16 | 101 | 15.84% |
| Alzheimer’s disease * | 0.037 | 19 | 75 | 25.3% |
| Autoimmune thyroid disease ** | 0.0004 | 18 | 72 | 25% |
| Allograft rejection ** | 0.0001 | 17 | 56 | 33.36% |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) ** | 0.0 | 22 | 74 | 29.73% |
| Dilated cardiomyopathy ** | 0.0 | 24 | 89 | 26.97% |
| Hypertrophic cardiomyopathy (HCM) ** | 0.0 | 24 | 83 | 28.92% |
| Cell growth and death | ||||
| Natural killer cell mediated cytotoxicity ** | 0.005 | 22 | 125 | 17.6% |
| Mitogen-activated protein kinase (MAPK) signaling pathway * | 0.0136 | 37 | 296 | 13.75% |
| Ras-Independent pathway in NK cell-mediated cytotoxicity * | 0.0313 | 5 | 17 | 29.41% |
| p53 signaling pathway * | 0.038 | 18 | 70 | 25.7% |
| Sexual maturity | ||||
| Maturity onset diabetes of the young * | 0.0453 | 6 | 26 | 23.08% |
| Oocyte meiosis * | 0.043 | 17 | 114 | 14.91% |
| GnRH signaling pathway * | 0.024 | 23 | 99 | 23.23% |
| Metabolism of xenobiotics by cytochrome P450 * | 0.011 | 11 | 78 | 15.1% |
| Neural development | ||||
| IL12 and Stat4 Dependent Signaling Pathway in Th1 Development ** | 0.0082 | 7 | 22 | 31.82% |
| Th1/Th2 Differentiation ** | 0.0034 | 7 | 18 | 38.89% |
| Neurotrophin signaling pathway * | 0.043 | 17 | 50 | 34% |
| Osteoclast differentiation * | 0.032 | 13 | 75 | 17.3% |
Hit represents the numbers of differentially expressed genes identified by microarray hybridization on the given term. Total represents the total gene numbers on the given term. Percent means the % of hit to total. * means p < 0.05 representing a significant difference; and ** means p < 0.01 representing a highly significant difference.