Figure 5.

Chemical similarity to known tyrosinase inhibitors. Distribution of ΣTc values in (A) all 469 inhibitors; (B) 107 thione-containing inhibitors; and (C) 78 thiourea-containing inhibitors from BindingDB [38]. The values of ΣTc were calculated between all the inhibitors and individual sets of inhibitors. (A–C) have the same bin ranges in X-axis. The counts (N) in Y-axis are scaled logarithmically for clarity. The shaded ranges with pink colour in (A–C) corresponds to 3, 4, and 5–9 compounds with the values of ΣTc described in Table 4.