Table 1.

Details of the compounds tested in this study for the inhibition of mushroom tyrosinase.

ID †	Chemical	2D Structure	ZINC ID	Mw	IC50 (μM)	LE ‡
1	Phenylthiourea (PTU)		ZINC03875720	152	1	0.84
2	Kojic acid		ZINC13831818	142	29	0.64
3	Thioacetazone		ZINC17970372	236	14	0.43
4	Ambazone		ZINC18066619	237	15	0.42
5	Methimazole		ZINC01187543	114	94	0.81
6	Carbimazole		ZINC00001091	186	>2000	-
7	Thiouracil		ZINC05127810	128	215	0.64
8	Methylthiouracil		ZINC05037820	142	266	0.56
9	Propylthiouracil		ZINC04640636	170	375	0.44

^† All chemicals in following Table 2, Table 3 and Table 4 have the identical IDs to those in Table 1; MW and IC₅₀ mean molecular weight and half maximal inhibitory concentration, respectively; ^‡ LE indicates ligand efficiency that is defined as 1.4 × (−log₁₀IC₅₀)/N, where N is the number of non-hydrogen atoms [32].