Table 3.
Effects of tyrosinase inhibitors on cell survival, melanin content, and cell lysates of mammalian B16F10 cells †.
| ID | MTT (%) | Melanin Content (%) ‡ | Cell Lysate (%) § |
|---|---|---|---|
| 20 µM | 20 µM | ||
| 1 | 113 ± 10 | 59 ± 7 | 5 ± 1 |
| 2 | 114 ± 10 | 108 ± 11 | 86 ± 8 |
| 3 | 95 ± 15 | 102 ± 10 | 74 ± 7 |
| 4 | 95 ± 12 | 80 ± 11 | 87 ± 9 |
| 5 | 100 ± 9 | 104 ± 12 | 93 ± 10 |
| 7 | 99 ± 10 | 106 ± 14 | 79 ± 9 |
| 8 | 108 ± 10 | 102 ± 14 | 78 ± 10 |
| 9 | 102 ± 12 | 102 ± 10 | 77 ± 9 |
† Each value is the mean ± standard deviation from triplicate trials; ‡ Melanin content with each inhibitor was scaled with that in the absence of inhibitor (100%) after treating IBMX 100 μM to B16F10 cells; § Inhibition of the enzyme with B16F10 cell lysates was scaled with that in the absence of inhibitor (100%).