Figure 5.

TDAG8 is involved in the regulation of LPS-induced cytokine and chemokine expression. Mice (WT and TDAG8^TP/TP) were treated with PBS or LPS as described in Figure 3. Cytokine (TNF-α, IL-6) and chemokine (KC/CXCL1, MIP-2/CXCL2) expression levels were evaluated 2 h after intratracheal instillation. (A) The mRNA expression of the lungs. Results are expressed as relative ratio to GAPDH; (B) The cytokine and chemokine protein level of the BAL fluids. Results are expressed as ng proteins/mL. Data are mean ± SEM of n = 4–10 for each group. The effect of TDAG8 deficiency is significant, * p < 0.05 (TDAG8^TP/TP-LPS vs. WT-LPS).