Skip to main content
. 2015 Dec 8;16(12):29265–29277. doi: 10.3390/ijms161226164

Figure 5.

Figure 5

MSU crystal-induced chondrocyte death was independent of (A) pyroptosis and (B) necroptosis. Chondrocytes were exposed to (A) Ac-YVAD-CHO (YVAD; 10, 30, 50, and 100 ng/mL) or (B) necrostatin-1 (Nec-1; 30 µM) 3 h prior to treatment with MSU crystals (200 µg/mL) for 24 h. Cell viability was measured by a LDH release assay. Data represent the mean ± SD for triplicate experiments from three different donors. (A) ** p < 0.01 vs. YVAD-only treated cells; (B) **** p < 0.001 vs. untreated cells. (A) White bar, without MSU crystals; black bar, with MSU crystals.