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Changes in plasma CLZ concentration after intravenous injection of CLZ solution or CLZnano dispersion. 0.3 mL of CLZ solution (open circles) or CLZnano dispersion (closed circles) was injected into the femoral vein (0.1 mg/kg), and venous blood (200 μL) was collected. Solid lines present fitting curves for plasma CLZ fates after intravenous administration of CLZ solution or CLZnano dispersion. The data are presented as means ± S.E. of seven independent rats.
