Table 1.
Association of nucleosomes, H3K27me3, H3K9me3, and H4K20me3 with clinical characteristics.
| Variables | Number of Patients (%) | Nucleosomes (OD) | H3K27me3 (%) | H3K9me3 (%) | H4K20me3 (%) | ||||
|---|---|---|---|---|---|---|---|---|---|
| Median | p-Value | Median | p-Value | Median | p-Value | Median | p-Value | ||
| Age | |||||||||
| ≥60 years | 30 (47.6) | 0.43 | 0.01 | 54.55 | 0.25 | 29.70 | 0.69 | 8.20 | 0.72 |
| <60 years | 33 (52.3) | 0.31 | 36.10 | 33.10 | 8.40 | ||||
| Gender | |||||||||
| Male | 36 (57.1) | 0.39 | 0.99 | 51.55 | 0.54 | 29.70 | 0.45 | 10.25 | 0.29 |
| Female | 27 (42.8) | 0.39 | 36.10 | 34.70 | 8.20 | ||||
| Diameter | |||||||||
| ≥5 cm | 32 (50.7) | 0.42 | 0.75 | 51.55 | 0.82 | 37.40 | 0.22 | 9.55 | 0.10 |
| <5 cm | 31 (49.2) | 0.36 | 36.10 | 29.30 | 7.80 | ||||
| Differentiation | |||||||||
| Well + Moderate | 49 (77.7) | 0,37 | 0.42 | 38.90 | 0.52 | 31.30 | 0.90 | 8.20 | 0.25 |
| Poor | 14 (22.2) | 0.42 | 58.10 | 36.20 | 9 | ||||
| Lymphatic Metastasis | |||||||||
| N0 | 30 (47.6) | 0.40 | 0.89 | 49.65 | 0.90 | 30.90 | 0.73 | 8.30 | 0.75 |
| N1-3 | 33 (52.3) | 0.37 | 37.20 | 32.10 | 8.40 | ||||
| Distal Metastasis a | |||||||||
| M0 | 52 (85.2) | 0.40 | 0.59 | 40 | 0.54 | 30.25 | 0.54 | 8.35 | 0.75 |
| M1 | 9 (14.7) | 0.44 | 33.4 | 38.40 | 8.30 | ||||
| TNM Stage | |||||||||
| I–II | 28 (44.4) | 0.42 | 0.41 | 49.65 | 0.59 | 30.90 | 0.92 | 8.30 | 0.76 |
| III–IV | 35 (55.5) | 0.36 | 37.20 | 32.10 | 8.40 | ||||
| Tumor Localization | |||||||||
| Right | 27 (42.8) | 0.41 | 0.94 | 48.70 | 0.74 | 33.10 | 0.37 | 10.20 | 0.29 |
| Left | 36 (57.1) | 0.37 | 39.95 | 30.70 | 8.25 | ||||
| Venous Invasion b | |||||||||
| No | 46 (80.7) | 0.41 | 0.80 | 38.95 | 0.87 | 30.05 | 0.30 | 8.50 | 0.15 |
| Yes | 11 (19.2) | 0.37 | 66.50 | 37.40 | 8.20 | ||||
| Crohn’s-like c | |||||||||
| No | 39 (69.6) | 0.37 | 0.67 | 33.40 | 0.25 | 29.30 | 0.19 | 8.30 | 0.01 |
| Yes | 17 (30.3) | 0.42 | 48.70 | 34.70 | 11.70 | ||||
| Lymphocyte Invasion c | |||||||||
| No | 44 (78.5) | 0.4 | 0.06 | 46.80 | 0.28 | 29.7 | 0.33 | 8.45 | 0.03 |
| Yes | 12 (21.4) | 0.3 | 34.75 | 36.1 | 14.45 | ||||
| Perineural Invasion | |||||||||
| No | 38 (67.8) | 0.40 | 0.40 | 41.95 | 0.81 | 30.05 | 0.45 | 8.40 | 0.93 |
| Yes | 18 (32.1) | 0.36 | 32.20 | 36.70 | 9 | ||||
| Mesenteric Tumor Nodules c | |||||||||
| No | 38 (67.8) | 0.40 | 0.81 | 35.95 | 0.22 | 31.60 | 0.69 | 8.50 | 0.90 |
| Yes | 18 (32.1) | 0.33 | 55.75 | 30.85 | 8.90 | ||||
| CEA a | |||||||||
| ≤5 ng/mL | 35 (57.3) | 0.36 | 0.63 | 41 | 0.76 | 32.1 | 0.87 | 8.30 | 0.74 |
| >5 ng/mL | 26 (42.6) | 0.41 | 51.55 | 32.7 | 8.55 | ||||
| CA 19-9 a | |||||||||
| ≤34 U/mL | 51 (83.6) | 0.39 | 0.86 | 41 | 0.70 | 31.70 | 0.26 | 8.20 | 0.17 |
| >34 U/mL | 10 (16.3) | 0.39 | 51.7 | 37.35 | 10.60 | ||||
a Not available for 2 patients; b Not available for 6 patients; c Not available for 7 patients. Bold p values indicate statistical significance.